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Biological effeects of new hydraulic materials on human periodontal ligament stem cells

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Biological effeects of new hydraulic materials on human periodontal ligament stem cells

dc.contributor.author	López-García, Sergio
dc.contributor.author	Lozano, Adrián
dc.contributor.author	García-Bernal, David
dc.contributor.author	Forner Navarro, Leopoldo
dc.contributor.author	Llena Puy, María Carmen
dc.contributor.author	Guerrero Gironés, Julia
dc.contributor.author	Moraleda Jiménez, Jose Maria
dc.contributor.author	Murcia, L.
dc.contributor.author	Rodríguez Lozano, Francisco Javier
dc.date.accessioned	2022-05-16T11:22:03Z
dc.date.available	2022-05-16T11:22:03Z
dc.date.issued	2019
dc.identifier.citation	López-García, Sergio Lozano, Adrián García-Bernal, David Forner Navarro, Leopoldo Llena Puy, María Carmen Guerrero Gironés, Julia Moraleda Jiménez, Jose Maria Murcia, L. Rodríguez Lozano, Francisco Javier 2019 Biological effeects of new hydraulic materials on human periodontal ligament stem cells Journal Of Clinical Medicine 8 8 1216
dc.identifier.uri	https://hdl.handle.net/10550/82783
dc.description.abstract	Abstract: Background: The aim of this study was: to evaluate the biological properties of new hydraulic materials: Bio-C Repair and Bio-C Sealer. Methods: Periodontal ligament stem cells were exposed to several dilutions of Bio-C Repair and Bio-C Sealer. The ion release profile and pH were determined. Metabolic activity, cell migration and cell survival were assessed using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT), wound-healing assays and Annexin assays, respectively. Cells were cultured in direct contact with the surface of each material. These were then analyzed via scanning electron microscopy (SEM) and energy dispersive X-ray (EDX). Statistical differences were assessed using a two-way ANOVA (α < 0.05). Results: Similar pH was observed in these cements. Bio-C Sealer released significantly more Ca and Si ions (p < 0.05) in comparison with Bio-C Repair. Undiluted Bio-C Sealer induced a significant reduction on cellular viability, cell survival and cell migration when compared to the control (p < 0.05). Moreover, SEM showed abundant cells adhered on Bio-C Repair and a moderate number of cells attached on Bio-C Sealer. Finally, EDX analysis identified higher percentages of Ca and O in the case of Bio-C repair than with Bio-C sealer, while other elements such as Zr and Si were more abundant in Bio-C sealer. Conclusions: Bio-C Repair displayed higher cell viability, cell adhesion and migration rates than Bio-C Sealer.
dc.language.iso	eng
dc.relation.ispartof	Journal Of Clinical Medicine, 2019, vol. 8, num. 8, p. 1216
dc.subject	Odontologia
dc.title	Biological effeects of new hydraulic materials on human periodontal ligament stem cells
dc.type	journal article	es_ES
dc.date.updated	2022-05-16T11:22:03Z
dc.identifier.doi	10.3390/jcm8081216
dc.identifier.idgrec	137953
dc.rights.accessRights	open access	es_ES