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Inmediato y after effects de transcraneal direct-current stimulation in mouse primary somatosensory cortex.

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Inmediato y after effects de transcraneal direct-current stimulation in mouse primary somatosensory cortex.

dc.contributor.author	Sánchez-León, Carlos A.
dc.contributor.author	Cordones, Isabel
dc.contributor.author	Ammann, Claudia
dc.contributor.author	Ausín, José M.
dc.contributor.author	Gómez-Climent, María A.
dc.contributor.author	Carretero-Guillén, Alejandro
dc.contributor.author	Sánchez-Garrido Campo, Guillermo s
dc.contributor.author	Gruart, Agnès
dc.contributor.author	Delgado-García, José M.
dc.contributor.author	Cheron, Guy
dc.contributor.author	Medina, Javier F.
dc.contributor.author	Márquez-Ruiz, Javier
dc.date.accessioned	2022-06-13T17:31:35Z
dc.date.available	2022-06-13T17:31:35Z
dc.date.issued	2021
dc.identifier.citation	Sánchez-León, Carlos A. Cordones, Isabel Ammann, Claudia Ausín, José M. Gómez-Climent, María A. Carretero-Guillén, Alejandro Sánchez-Garrido Campo, Guillermo s Gruart, Agnès Delgado-García, José M. Cheron, Guy Medina, Javier F. Márquez-Ruiz, Javier 2021 Inmediato y after effects de transcraneal direct-current stimulation in mouse primary somatosensory cortex. Scientific Reports 11 3123
dc.identifier.uri	https://hdl.handle.net/10550/83114
dc.description.abstract	Transcranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique consisting in the application of weak electric currents on the scalp. Although previous studies have demonstrated the clinical value of tDCS for modulating sensory, motor, and cognitive functions, there are still huge gaps in the knowledge of the underlying physiological mechanisms. To define the immediate impact as well as the after effects of tDCS on sensory processing, we first performed electrophysiological recordings in primary somatosensory cortex (S1) of alert mice during and after administration of S1-tDCS, and followed up with immunohistochemical analysis of the stimulated brain regions. During the application of cathodal and anodal transcranial currents we observed polarity-specific bidirectional changes in the N1 component of the sensory-evoked potentials (SEPs) and associated gamma oscillations. On the other hand, 20 min of cathodal stimulation produced significant after-effects including a decreased SEP amplitude for up to 30 min, a power reduction in the 20-80 Hz range and a decrease in gamma event related synchronization (ERS). In contrast, no significant changes in SEP amplitude or power analysis were observed after anodal stimulation except for a significant increase in gamma ERS after tDCS cessation. The polarity-specific differences of these after effects were corroborated by immunohistochemical analysis, which revealed an unbalance of GAD 65-67 immunoreactivity between the stimulated versus non-stimulated S1 region only after cathodal tDCS. These results highlight the differences between immediate and after effects of tDCS, as well as the asymmetric after effects induced by anodal and cathodal stimulation.
dc.language.iso	eng
dc.relation.ispartof	Scientific Reports, 2021, vol. 11, num. 3123
dc.subject	Ciència Ensenyament
dc.subject	Aprenentatge sensoriomotor
dc.subject	Adaptació (Psicologia)
dc.subject	Cervell Localització de funcions
dc.title	Inmediato y after effects de transcraneal direct-current stimulation in mouse primary somatosensory cortex.
dc.type	journal article	es_ES
dc.date.updated	2022-06-13T17:31:35Z
dc.identifier.doi	10.1038/s41598-021-82364-4
dc.identifier.idgrec	152484
dc.rights.accessRights	open access	es_ES