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c‑MYC Triggers Lipid Remodelling During Early Somatic Cell Reprogramming to Pluripotency

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c‑MYC Triggers Lipid Remodelling During Early Somatic Cell Reprogramming to Pluripotency

dc.contributor.author	Prieto Martínez, Javier
dc.contributor.author	García Cañaveras, Juan Carlos
dc.contributor.author	León Rodríguez, Marian
dc.contributor.author	Sendra Pérez, Ramón
dc.contributor.author	Ponsoda i Martí, Xavier
dc.contributor.author	Izpisúa Belmonte, Juan Carlos
dc.contributor.author	Lahoz Rodríguez, Agustín
dc.contributor.author	Torres Ibáñez, José Manuel
dc.date.accessioned	2022-10-20T17:54:11Z
dc.date.available	2022-10-20T17:54:11Z
dc.date.issued	2021
dc.identifier.citation	Prieto Martínez, Javier García Cañaveras, Juan Carlos León Rodríguez, Marian Sendra Pérez, Ramón Ponsoda i Martí, Xavier Izpisúa Belmonte, Juan Carlos Lahoz Rodríguez, Agustín Torres Ibáñez, José Manuel 2021 c‑MYC Triggers Lipid Remodelling During Early Somatic Cell Reprogramming to Pluripotency Stem Cell Reviews And Reports 17 2245 2261
dc.identifier.uri	https://hdl.handle.net/10550/84229
dc.description.abstract	Metabolic rewiring and mitochondrial dynamics remodelling are hallmarks of cell reprogramming, but the roles of the reprogramming factors in these changes are not fully understood. Here we show that c-MYC induces biosynthesis of fatty acids and increases the rate of pentose phosphate pathway. Time-course profiling of fatty acids and complex lipids during cell reprogramming using lipidomics revealed a profound remodelling of the lipid content, as well as the saturation and length of their acyl chains, in a c-MYC-dependent manner. Pluripotent cells displayed abundant cardiolipins and scarce phosphatidylcholines, with a prevalence of monounsaturated acyl chains. Cells undergoing cell reprogramming showed an increase in mitochondrial membrane potential that paralleled that of mitochondrial-specific cardiolipins. We conclude that c-MYC controls the rewiring of somatic cell metabolism early in cell reprogramming by orchestrating cell proliferation, synthesis of macromolecular components and lipid remodelling, all necessary processes for a successful phenotypic transition to pluripotency.
dc.language.iso	eng
dc.relation.ispartof	Stem Cell Reviews And Reports, 2021, vol. 17, p. 2245-2261
dc.subject	Cèl·lules
dc.subject	Càncer
dc.title	c‑MYC Triggers Lipid Remodelling During Early Somatic Cell Reprogramming to Pluripotency
dc.type	journal article	es_ES
dc.date.updated	2022-10-20T17:54:11Z
dc.identifier.doi	10.1007/s12015-021-10239-2
dc.identifier.idgrec	155019
dc.rights.accessRights	open access	es_ES