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Recent Advances in Catalytic Enantioselective Synthesis of Pyrazolones with a Tetrasubstituted Stereogenic Center at the 4-Position

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Recent Advances in Catalytic Enantioselective Synthesis of Pyrazolones with a Tetrasubstituted Stereogenic Center at the 4-Position

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dc.contributor.author	Carceller-Ferrer, Laura
dc.contributor.author	Blay Llinares, Gonzalo
dc.contributor.author	Pedro, José Ramón
dc.contributor.author	Vila Descals, Carlos
dc.date.accessioned	2022-11-30T17:59:08Z
dc.date.available	2022-11-30T17:59:08Z
dc.date.issued	2021
dc.identifier.citation	Carceller-Ferrer, Laura Blay Llinares, Gonzalo Pedro, José Ramón Vila Descals, Carlos 2021 Recent Advances in Catalytic Enantioselective Synthesis of Pyrazolones with a Tetrasubstituted Stereogenic Center at the 4-Position Synthesis-Stuttgart 53 02 215 237
dc.identifier.uri	https://hdl.handle.net/10550/84647
dc.description.abstract	Pyrazolone [2,4-dihydro-3H-pyrazol-4-one] represents one of the most important five-membered nitrogen heterocycles which is present in numerous pharmaceutical drugs and molecules with biological activity. Recently, many catalytic methodologies for the asymmetric synthesis of chiral pyrazolones have been established with great success, specially, for the synthesis of pyrazolones bearing a tetrasubstituted stereocenter at C-4. This review summarizes these excellent research studies since 2018, including representative examples and some mechanistic pathways explaining the observed stereochemistry.
dc.language.iso	eng
dc.relation.ispartof	Synthesis-Stuttgart, 2021, vol. 53, num. 02, p. 215-237
dc.subject	Catàlisi
dc.subject	Compostos de nitrogen
dc.subject	Compostos heterocíclics
dc.title	Recent Advances in Catalytic Enantioselective Synthesis of Pyrazolones with a Tetrasubstituted Stereogenic Center at the 4-Position
dc.type	journal article	es_ES
dc.date.updated	2022-11-30T17:59:08Z
dc.identifier.doi	10.1055/s-0040-1707298
dc.identifier.idgrec	142198
dc.rights.accessRights	open access	es_ES