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Organocatalytic enantioselective 1,6-aza-Michael addition of isoxazolin-5-ones to p-quinone methides

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Organocatalytic enantioselective 1,6-aza-Michael addition of isoxazolin-5-ones to p-quinone methides

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dc.contributor.author	Torán, Ricardo
dc.contributor.author	Vila Descals, Carlos
dc.contributor.author	Sanz Marco, Amparo
dc.contributor.author	Muñoz, M. Carmen
dc.contributor.author	Pedro, José Ramón
dc.contributor.author	Blay Llinares, Gonzalo
dc.date.accessioned	2022-12-13T15:29:36Z
dc.date.available	2022-12-13T15:29:36Z
dc.date.issued	2020
dc.identifier.citation	Torán, Ricardo Vila Descals, Carlos Sanz Marco, Amparo Muñoz, M. Carmen Pedro, José Ramón Blay Llinares, Gonzalo 2020 Organocatalytic enantioselective 1,6-aza-Michael addition of isoxazolin-5-ones to p-quinone methides European Journal of Organic Chemistry 2020 5 627 630
dc.identifier.uri	https://hdl.handle.net/10550/84746
dc.description.abstract	A thiourea-Brønsted base bifunctional catalyst allowed the enantioselective 1,6-aza-Michael addition of isoxazolin-5-ones to p-quinone methides to give isoxazolin-5-ones having a chiral diarylmethyl moiety attached to the N atom with fair to good yields and enantiomeric excesses. To the best of our knowledge this reaction represents the first example of enantioselective N-alkylation of isoxazolin-5-ones as well as the first example of enantioselective 1,6-aza-Michael reaction involving p-quinone methides.
dc.language.iso	eng
dc.relation.ispartof	European Journal of Organic Chemistry, 2020, vol. 2020, num. 5, p. 627-630
dc.subject	Catàlisi
dc.subject	Compostos heterocíclics
dc.subject	Química orgànica
dc.title	Organocatalytic enantioselective 1,6-aza-Michael addition of isoxazolin-5-ones to p-quinone methides
dc.type	journal article	es_ES
dc.date.updated	2022-12-13T15:29:37Z
dc.identifier.doi	10.1002/ejoc.201901907
dc.identifier.idgrec	136137
dc.rights.accessRights	open access	es_ES