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Genomic Signature in Evolutionary Biology: A Review

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Genomic Signature in Evolutionary Biology: A Review

dc.contributor.author	De la Fuente, Rebeca
dc.contributor.author	Díaz Villanueva, Wladimiro
dc.contributor.author	Arnau Llombart, Vicente
dc.contributor.author	Moya, Andrés
dc.date.accessioned	2023-03-07T13:36:15Z
dc.date.available	2023-03-07T13:36:15Z
dc.date.issued	2023
dc.identifier.citation	De la Fuente, Rebeca Díaz Villanueva, Wladimiro Arnau Llombart, Vicente Moya, Andrés 2023 Genomic Signature in Evolutionary Biology: A Review Biology-Basel 12 322 1 24
dc.identifier.uri	https://hdl.handle.net/10550/85701
dc.description.abstract	Organisms are unique physical entities in which information is stored and continuously processed. The digital nature of DNA sequences enables the construction of a dynamic information reservoir. However, the distinction between the hardware and software components in the information flow is crucial to identify the mechanisms generating specific genomic signatures. In this work, we perform a bibliometric analysis to identify the different purposes of looking for particular patterns in DNA sequences associated with a given phenotype. This study has enabled us to make a conceptual breakdown of the genomic signature and differentiate the leading applications. On the one hand, it refers to gene expression profiling associated with a biological function, which may be shared across taxa. This signature is the focus of study in precision medicine. On the other hand, it also refers to characteristic patterns in species-specific DNA sequences. This interpretation plays a key role in comparative genomics, identifying evolutionary relationships. Looking at the relevant studies in our bibliographic database, we highlight the main factors causing heterogeneities in genome composition and how they can be quantified. All these findings lead us to reformulate some questions relevant to evolutionary biology. Keywords: genomic signature; chaos game representation; genome sequence; alignment-free methods; evolutionary biology
dc.language.iso	eng
dc.relation.ispartof	Biology-Basel, 2023, vol. 12, num. 322, p. 1-24
dc.subject	Biologia
dc.subject	Genoma humà
dc.title	Genomic Signature in Evolutionary Biology: A Review
dc.type	journal article	es_ES
dc.date.updated	2023-03-07T13:36:16Z
dc.identifier.doi	10.3390/biology12020322
dc.identifier.idgrec	157029
dc.rights.accessRights	open access	es_ES