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The effect of Holder pasteurization on the lipid and metabolite composition of human milk

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The effect of Holder pasteurization on the lipid and metabolite composition of human milk

dc.contributor.author	Moreno Torres, Marta
dc.contributor.author	Ten Doménech, Isabel
dc.contributor.author	Ramos García, Victoria
dc.contributor.author	Parra Llorca, Anna
dc.contributor.author	María Gormaz
dc.contributor.author	Vento Torres, Máximo
dc.contributor.author	Kuligowski, Julia
dc.contributor.author	Quintás Soriano, Guillermo
dc.date.accessioned	2023-05-18T09:50:28Z
dc.date.available	2023-05-18T09:50:28Z
dc.date.issued	2022
dc.identifier.citation	Moreno Torres, Marta Ten Doménech, Isabel Ramos Garcia, Victoria Parra Llorca, Anna María Gormaz Vento Torres, Máximo Kuligowski, Julia Quintás Soriano, Guillermo 2022 The effect of Holder pasteurization on the lipid and metabolite composition of human milk Food Chemistry 384 1 9
dc.identifier.uri	https://hdl.handle.net/10550/86694
dc.description.abstract	Human milk (HM) is the gold standard for newborn nutrition. When own mother's milk is not sufficiently available, pasteurized donor human milk becomes a valuable alternative. In this study we analyzed the impact of Holder pasteurization (HoP) on the metabolic and lipidomic composition of HM. Metabolomic and lipidomic profiles of twelve paired HM samples were analysed before and after HoP by liquid chromatography-mass spectrometry (MS) and gas chromatography-MS. Lipidomic analysis enabled the annotation of 786 features in HM out of which 289 were significantly altered upon pasteurization. Fatty acid analysis showed a significant decrease of 22 out of 29 detectable fatty acids. The observed changes were associated to five metabolic pathways. Lipid ontology enrichment analysis provided insight into the effect of pasteurization on physical and chemical properties, cellular components, and functions. Future research should focus on nutritional and/or developmental consequences of these changes.
dc.language.iso	eng
dc.relation.ispartof	Food Chemistry, 2022, vol. 384, p. 1-9
dc.subject	Bioquímica
dc.subject	Biologia
dc.subject	Nutrició
dc.title	The effect of Holder pasteurization on the lipid and metabolite composition of human milk
dc.type	journal article
dc.date.updated	2023-05-18T09:50:29Z
dc.identifier.doi	10.1016/j.foodchem.2022.132581
dc.identifier.idgrec	158852
dc.rights.accessRights	open access