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Analysis of the Association between Fatigue and the Plasma Lipidomic Profile of Inflammatory Bowel Disease Patients

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Analysis of the Association between Fatigue and the Plasma Lipidomic Profile of Inflammatory Bowel Disease Patients

dc.contributor.author	Moreno Torres, Marta
dc.contributor.author	Horta, Diana
dc.contributor.author	Ramírez Lázaro, María José
dc.contributor.author	Lario, Sergio
dc.contributor.author	Kuligowski, Julia
dc.contributor.author	Sanjuan Herráez, Juan Daniel
dc.contributor.author	Quintás Soriano, Guillermo
dc.contributor.author	Villoria, Albert
dc.contributor.author	Calvet, Xavier
dc.date.accessioned	2023-05-19T07:49:02Z
dc.date.available	2023-05-19T07:49:02Z
dc.date.issued	2020
dc.identifier.citation	Moreno Torres, Marta Horta, Diana Ramírez Lázaro, María José Lario, Sergio Kuligowski, Julia Sanjuan Herráez, Juan Daniel Quintás Soriano, Guillermo Villoria, Albert Calvet, Xavier 2020 Analysis of the Association between Fatigue and the Plasma Lipidomic Profile of Inflammatory Bowel Disease Patients Journal of Proteome Research 20 1 381 392
dc.identifier.uri	https://hdl.handle.net/10550/86700
dc.description.abstract	Inflammatory bowel disease (IBD) is a chronic, relapsing noninfectious inflammatory condition of the intestinal tract with two main phenotypes, ulcerative colitis (UC) and Crohn's disease (CD), and globally increasing incidence and prevalence. Nearly 80% of the IBD patients with active disease and 50% of those with inactive disease suffer fatigue with significant impairment of their quality of life. Fatigue has been associated with multiple factors in IBD patients but, in most cases, no direct cause can be identified, and risk factors in clinically quiescent IBD are contradictory. Furthermore, as the assessment of fatigue is subjective, there is an unmet clinical need for fatigue biomarkers. In this explorative study, we analyzed the plasma lipidomic profiles of 47 quiescent UC and CD patients (23 fatigued, 24 nonfatigued) using ultraperformance liquid chromatography-time-of-flight mass spectrometry (UPLC-TOFMS). The results showed changes in lipids associated with fatigue and IBD. Significantly decreased levels of phosphatidylcholines, plasmanyls, sphingomyelins, lysophosphatidylcholines, phosphatidylethanolamines, phosphatidylinositols, phosphatidylserines, and eicosanoids were observed in patients with fatigue. Network and metabolic pathway analysis indicated a dysregulation of the arachidonic acid and glycerophospholipid metabolisms and the sphingolipid pathway. The protein-metabolite interaction network showed interactions between functionally related metabolites and proteins, displaying 40 disease-associated hidden proteins including ABDH4, GLTP, and LCAT.
dc.language.iso	eng
dc.relation.ispartof	Journal of Proteome Research, 2020, vol. 20, num. 1, p. 381-392
dc.subject	Bioquímica
dc.subject	Biologia
dc.title	Analysis of the Association between Fatigue and the Plasma Lipidomic Profile of Inflammatory Bowel Disease Patients
dc.type	journal article
dc.date.updated	2023-05-19T07:49:02Z
dc.identifier.doi	10.1021/acs.jproteome.0c00462
dc.identifier.idgrec	158853
dc.rights.accessRights	open access