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Short-term outcomes of colorectal cancer surgery in older patients : a novel nomogram predicting postoperative morbi-mortality

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Short-term outcomes of colorectal cancer surgery in older patients : a novel nomogram predicting postoperative morbi-mortality

dc.contributor.author	Moro Valdezate, David
dc.contributor.author	Martín Arévalo, José
dc.contributor.author	Ferro Echevarría, Óscar
dc.contributor.author	Pla Martí, Vicente
dc.contributor.author	García Botello, Stephanie Anne
dc.contributor.author	Pérez Santiago, Leticia
dc.contributor.author	Gadea Mateo, Ricardo
dc.contributor.author	Tarazona Llavero, Noelia
dc.contributor.author	Roda Perez, Desamparados
dc.contributor.author	Roselló Keränen, Susana
dc.contributor.author	Espí Macías, Alejandro
dc.date.accessioned	2023-05-22T17:06:45Z
dc.date.available	2023-05-22T17:06:45Z
dc.date.issued	2022
dc.identifier.citation	Moro Valdezate, David Martín Arévalo, José Ferro Echevarría, Óscar Pla Martí, Vicente García Botello, Stephanie Anne Pérez Santiago, Leticia Gadea Mateo, Ricardo Tarazona Llavero, Noelia Roda Perez, Desamparados Roselló Keränen, Susana Espí Macías, Alejandro 2022 Short-term outcomes of colorectal cancer surgery in older patients : a novel nomogram predicting postoperative morbi-mortality Langenbecks Archives of Surgery
dc.identifier.uri	https://hdl.handle.net/10550/86828
dc.description.abstract	Purpose To analyze short-term outcomes of curative-intent cancer surgery in all adult patients diagnosed with colorectal cancer undergoing surgery from January 2010 to December 2019 and determine risk factors for postoperative complications and mortality. Methods Retrospective study conducted at a single tertiary university institution. Patients were stratified by age into two groups: < 75 years and ≥ 75 years. Primary outcome was the influence of age on 30-day complications and mortality. Inde- pendent risk factors for postoperative adverse events or mortality were analyzed, and two novel nomograms were constructed. Results Of the 1486 patients included, 580 were older (≥ 75 years). Older subjects presented more comorbidities and tumors were located mainly in right colon (45.7%). After matching, no between-group differences in surgical postoperative com- plications were observed. The 30-day mortality rate was 5.3% for the older and 0.8% for the non-older group (p < 0.001). In multivariable analysis, the independent risk factors for postoperative complications were peripheral vascular disease, chronic pulmonary disease, severe liver disease, postoperative transfusion, and surgical approach. Independent risk factors for 30-day mortality were age ≥ 80 years, cerebrovascular disease, severe liver disease, and postoperative transfusion. The model was internally and externally validated, showing high accuracy. Conclusion Patientsaged≥75yearshadsimilarpostoperativecomplicationsbuthigher30-daymortalitythantheiryounger counterparts. Patients with peripheral vascular disease, chronic pulmonary disease, or severe liver disease should be informed of higher postoperative complications. But patients aged ≥ 80 suffering cerebrovascular disease, severe liver disease, or need- ing postoperative transfusion should be warned of significantly increased risk of postoperative mortality.
dc.language.iso	eng
dc.relation.ispartof	Langenbecks Archives of Surgery, 2022
dc.subject	Càncer Cirurgia
dc.subject	Persones grans
dc.title	Short-term outcomes of colorectal cancer surgery in older patients : a novel nomogram predicting postoperative morbi-mortality
dc.type	journal article
dc.date.updated	2023-05-22T17:06:46Z
dc.identifier.doi	10.1007/s00423-022-02688-1
dc.identifier.idgrec	159423
dc.rights.accessRights	open access