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Lung Fibrosis and Fibrosis in the Lungs: Is It All about Myofibroblasts?

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Lung Fibrosis and Fibrosis in the Lungs: Is It All about Myofibroblasts?

dc.contributor.author	Ortiz Zapater, Elena
dc.contributor.author	Signes-Costa Miñana, Jaume
dc.contributor.author	Montero Magalló, Paula
dc.contributor.author	Roger Laparra, Inés
dc.date.accessioned	2023-05-30T14:21:48Z
dc.date.available	2023-05-30T14:21:48Z
dc.date.issued	2022
dc.identifier.citation	Ortiz Zapater, Elena Signes-Costa Miñana, Jaume Montero Magalló, Paula Roger Laparra, Inés 2022 Lung Fibrosis and Fibrosis in the Lungs: Is It All about Myofibroblasts? Biomedicines 10 6 1423
dc.identifier.uri	https://hdl.handle.net/10550/87124
dc.description.abstract	In the lungs, fibrosis is a growing clinical problem that results in shortness of breath and can end up in respiratory failure. Even though the main fibrotic disease affecting the lung is idiopathic pulmonary fibrosis (IPF), which affects the interstitial space, there are many fibrotic events that have high and dangerous consequences for the lungs. Asthma, chronic obstructive pulmonary disease (COPD), excessive allergies, clearance of infection or COVID-19, all are frequent diseases that show lung fibrosis. In this review, we describe the different kinds of fibrosis and analyse the main types of cells involved¿myofibroblasts and other cells, like macrophages¿and review the main fibrotic mechanisms. Finally, we analyse present treatments for fibrosis in the lungs and highlight potential targets for anti-fibrotic therapies.
dc.language.iso	eng
dc.relation.ispartof	Biomedicines, 2022, vol. 10, num. 6, p. 1423
dc.subject	Pulmons Malalties
dc.subject	Aparell respiratori Malalties
dc.title	Lung Fibrosis and Fibrosis in the Lungs: Is It All about Myofibroblasts?
dc.type	journal article
dc.date.updated	2023-05-30T14:21:49Z
dc.identifier.doi	10.3390/biomedicines10061423
dc.identifier.idgrec	159406
dc.rights.accessRights	open access