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High content and dispersion of Gd in bimodal porous silica: T2 contrast agents under ultra-high magnetic fields

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High content and dispersion of Gd in bimodal porous silica: T2 contrast agents under ultra-high magnetic fields

dc.contributor.author	Garrido, M. Dolores
dc.contributor.author	Puchol, Nuria
dc.contributor.author	El Haskouri, Jamal
dc.contributor.author	Sánchez Royo, Juan Francisco
dc.contributor.author	Folgado, José Vicente
dc.contributor.author	Gonzalez Marrachelli, Vannina
dc.contributor.author	Pérez Terol, Itziar
dc.contributor.author	Ros Lis, José Vicente
dc.contributor.author	Marcos, M. Dolores
dc.contributor.author	Ruíz, Rafael
dc.contributor.author	Beltrán, Aurelio
dc.contributor.author	Morales, José Manuel
dc.contributor.author	Amorós, Pedro
dc.date.accessioned	2023-06-14T07:11:03Z
dc.date.available	2023-06-15T04:45:05Z
dc.date.issued	2022	es_ES
dc.identifier.citation	Garrido, M. D., Puchol, N., El Haskouri, J., Sanchez-Royo, J. F., Folgado, J. V., Marrachelli, V. G., ... & Amoros, P. (2022). High content and dispersion of Gd in bimodal porous silica: T2 contrast agents under ultra-high magnetic fields. Microporous and Mesoporous Materials, 336, 111863.	es_ES
dc.identifier.uri	https://hdl.handle.net/10550/87893
dc.description.abstract	Silica-based UVM-7-type bimodal mesoporous materials with high gadolinium content (∞ ≥ Si/Gd ≥ 13) have been synthesized through a one-pot surfactant-assisted procedure from hydroalcoholic solution using a cationic surfactant as template, and starting from atrane complexes of Gd and Si as inorganic precursors. The novel synthetic pathway developed in the study preserves the UVM-7-type architecture while optimizing the dispersion of the Gd-guest species at the nanoscale and even at atomic level. It has been determined that the number of Gd atoms forming clusters is always less than 10. The behaviour under exposure to ultra-high magnetic fields reveals a significant increase in the transversal relaxivity value when compared with related materials in the bibliography. Their activity as T2 instead of T1 contrast agents is discussed and explained considering the high Gd-dispersion and concentration, nature of the materials as well as due to the high magnetic fields used, typical of MRM studies. The absence of toxicity has been confirmed in preliminary cell cultures “in vitro” and the degradation of the solids studied under biological conditions. Results suggest that the atrane route could be a suitable synthesis approach for the preparation of Gd containing contrast agents.	es_ES
dc.language.iso	en	es_ES
dc.publisher	Elsevier	es_ES
dc.subject	mesoporous	es_ES
dc.subject	silica	es_ES
dc.subject	gadolinium	es_ES
dc.subject	magnetic resonance image	es_ES
dc.subject	magnetic resonance microscopy	es_ES
dc.title	High content and dispersion of Gd in bimodal porous silica: T2 contrast agents under ultra-high magnetic fields	es_ES
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS TECNOLÓGICAS	es_ES
dc.identifier.doi	10.1016/j.micromeso.2022.111863	es_ES
dc.accrualmethod	CI	es_ES
dc.embargo.terms	0 days	es_ES
dc.type.hasVersion	VoR	es_ES
dc.rights.accessRights	open access	es_ES