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Periodontitis and alzheimer´s disease

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Periodontitis and alzheimer´s disease

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dc.contributor.author Sansores-España, Daniel es
dc.contributor.author Carrillo-Avila, Arelly es
dc.contributor.author Melgar-Rodriguez, Samanta es
dc.contributor.author Díaz-Zuñiga, Jaime es
dc.contributor.author Martínez-Aguilar, Victor es
dc.date.accessioned 2023-06-16T08:36:36Z
dc.date.available 2023-06-16T08:36:36Z
dc.date.issued 2021 es
dc.identifier.citation Sansores-España, D., Carrillo-Avila, A., Melgar-Rodriguez, S., Díaz-Zuñiga, J., & Martínez-Aguilar, V. (2021). Periodontitis and alzheimer´s disease. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e43-e48). Medicina Oral, S.L. https://doi.org/10.4317/medoral.23940 es
dc.identifier.uri https://hdl.handle.net/10550/87991
dc.description.abstract Alzheimer's disease (AD), the main cause of dementia in the adult population, is characterized by a progressive loss of cognitive function. It is considered that neuroinflammation plays a fundamental role in its onset and progression. The bacteria present in the disbiotic microbiome generated during the course of periodontitis (PE) are capable of inducing a systemic inflammatory response, exacerbating the production of proinflammatory mediators that have the potential to spread to the systemic circulation. Several hypotheses point to similar pathophysiological pathways in the establishment of AD and PE, sharing cellular and molecular proinflammatory characteristics. In periodontitis, locally produced cytokines and pro-inflammatory products spread from the ulcerated periodontal pocket into the systemic circulation, or around the trigeminal nerve terminals, which allows the passage of bacteria or their products to the brain. This fact leads to the formation of plaques of amyloid peptide and intraneuronal neurofibrillar tangles (NFTs) that activate the glial cells producing a significant increase in proinflammatory cytokines in the affected regions that lead to a loss of neuronal synapses and neurodegeneration, contributing to the progression of AD. This review of the literature contributes to the understanding of the pathological pathways shared by both diseases such as oxidative damage and inflammation. There is not enough evidence to determine an association between this two pathologies, so it is considered necessary to conduct studies for determine if periodontitis is capable of inducing or exacerbating the neuroinflammation that will trigger AD. es
dc.subject primary intraosseous squamous cell carcinoma es
dc.subject odontogenic keratocyst es
dc.subject prognosis es
dc.title Periodontitis and alzheimer´s disease es
dc.type journal article es_ES
dc.subject.unesco UNESCO:CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23940 es
dc.type.hasVersion VoR es_ES
dc.identifier.url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806353/

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