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Qualitative mucin disorders in patients with primary Sjögren's syndrome:a literature review

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Qualitative mucin disorders in patients with primary Sjögren's syndrome:a literature review

dc.contributor.author	Fusconi, Massimo	es
dc.contributor.author	Candelori, Francesca	es
dc.contributor.author	Weiss, Lior	es
dc.contributor.author	Riccio, Annachiara	es
dc.contributor.author	Priori, Roberta	es
dc.contributor.author	Businaro, Rita	es
dc.contributor.author	Mastromanno, Linda	es
dc.contributor.author	Musy, Isotta	es
dc.contributor.author	de Vincentiis, Marco	es
dc.contributor.author	Greco, Antonio	es
dc.date.accessioned	2023-06-16T08:36:37Z
dc.date.available	2023-06-16T08:36:37Z
dc.date.issued	2021	es
dc.identifier.citation	Fusconi, M., Candelori, F., Weiss, L., Riccio, A., Priori, R., Businaro, R., Mastromanno, L., Musy, I., de Vincentiis, M., & Greco, A. (2021). Qualitative mucin disorders in patients with primary Sjögren’s syndrome: a literature review. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e71-e77). Medicina Oral, S.L. https://doi.org/10.4317/medoral.23996	es
dc.identifier.uri	https://hdl.handle.net/10550/87995
dc.description.abstract	It is a common opinion that Primary Sjögren Syndrome (pSS) damages the exocrine glands and determines the reduction of secreted saliva, some studies show that there are qualitative anomalies of the mucins produced in saliva, including MUC7, MUC5B, MUC1. The purpose of this study is to trace all the information useful to establish whether there is a qualitative or quantitative defect of the mucins in the pSS. We reviewed the literature by looking for publications relevant to the topic in electronic databases. Sixteen articles met the search criteria. The studies were divided into two categories, those that studied the rheological characteristics of the saliva and those that studied the structural and / or metabolism modifications of the muciparous cells in the salivary glands. in Patients with pSS, xerostomia and the reduction of salivary spinnbarkeit are only partially related to the reduction of the unstimulated salivary flow. In pSS, pathological alterations of mucins? chemical-physical properties prevail as a cause of the clinical characteristics. Moreover, in pSS there are structural and metabolism changes in salivary glands? muciparous cells. There is much evidence that supports the presence of qualitative alterations in the saliva?s rheological properties in Patients with pSS, and these are the main cause, more than the reduction of the unstimulated salivary flow, of the disease clinical characteristics - dry mouth and complications in the oral cavity. Therefore we propose to add to the classification criteria of pSS also a qualitative test of salivary glycoproteins.	es
dc.subject	mouth neoplasms	es
dc.subject	squamous cell carcinoma	es
dc.subject	oral diagnosis	es
dc.title	Qualitative mucin disorders in patients with primary Sjögren's syndrome:a literature review	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.23996	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806352/