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Preemptive analgesia in dental implant surgery:a systematic review and meta-analysis of randomized controlled trials

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Preemptive analgesia in dental implant surgery:a systematic review and meta-analysis of randomized controlled trials

dc.contributor.author	Pereira, Gustavo-Mattos	es
dc.contributor.author	Martins Mussi, Maria Carolina	es
dc.contributor.author	Esteves Lima, Rafael Paschoal	es
dc.contributor.author	Alvarenga-Brant, Rachel	es
dc.contributor.author	Cota, Luis O.M.	es
dc.contributor.author	Costa, Fernando-Oliveira	es
dc.date.accessioned	2023-06-16T08:36:43Z
dc.date.available	2023-06-16T08:36:43Z
dc.date.issued	2021	es
dc.identifier.citation	Mattos-Pereira, GH., Martins, CC., Esteves-Lima, RP., Alvarenga-Brant, R., Cota, LO., & Costa, FO. (2021). Preemptive analgesia in dental implant surgery: A systematic review and meta-analysis of randomized controlled trials. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e632-e641). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24639	es
dc.identifier.uri	https://hdl.handle.net/10550/88069
dc.description.abstract	To assess the effectiveness of preemptive analgesia in dental implant surgery in randomized controlled trials (RCTs). The present study was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and registered in PROSPERO database CRD42020168757. A search without restrictions regarding language or date of publication was conducted in six databases and gray literature. A random effect meta-analysis compared the efficacy of preemptive analgesia compared to placebo through pooled OR and 95%CI. The interpretation of results followed the certainty of evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach together with the magnitude of the effect according to GRADE guidelines. Four studies were included in the review and three were incorporated into the meta-analysis. All studies demonstrated that preemptive analgesia contributed to a significant improvement in the postoperative pain control. However, the overall pooled standard mean difference (SMD) showed that preemptive analgesia had small effects compared to placebo in reducing pain (SMD: -0.45; IC: -0.83; -0.08) with low certainty of the evidence. Our meta-analysis showed that the magnitude of the effect was bigger six to eight hours after the surgery (large effect), compared to the time of one to two hours after the surgery (small effect). Preemptive analgesia may have a positive effect in reducing pain compared to not using preemptive medication, but the evidence is very uncertain.	es
dc.subject	acute myeloid leukemia	es
dc.subject	oral pathology	es
dc.subject	xerostomia	es
dc.subject	myeloablative conditioning	es
dc.subject	reduced-intensity conditioning	es
dc.title	Preemptive analgesia in dental implant surgery:a systematic review and meta-analysis of randomized controlled trials	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24639	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412441/