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Oral complaints in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation

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Oral complaints in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation

dc.contributor.author	Wysocka-Slowik, Aleksandra	es
dc.contributor.author	Gil, Lidia	es
dc.contributor.author	Slebioda, Zuzanna	es
dc.contributor.author	Dorocka Bobkowska, Barbara	es
dc.date.accessioned	2023-06-16T08:36:43Z
dc.date.available	2023-06-16T08:36:43Z
dc.date.issued	2021	es
dc.identifier.citation	Wysocka-Słowik, A., Gil, L., Ślebioda, Z., & Dorocka-Bobkowska, B. (2021). Oral complaints in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e642-e650). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24647	es
dc.identifier.uri	https://hdl.handle.net/10550/88070
dc.description.abstract	Acute myeloid leukemia belongs to proliferative diseases of the hematopoietic system. It is currently the leading indication for allogeneic hematopoietic stem cell transplantation. This study was designed to determine the most common subjective oral mucosa complaints in patients with acute myeloid leukemia after allogeneic hematopoietic cell transplantation, in relation to the type of conditioning used. Eighty patients diagnosed with acute myeloid leukemia were assigned to two groups depending on the intensity of the conditioning regimen before transplantation: myeloablative and reduced-intensity chemotherapy. The oral symptoms were evaluated based on an authorial questionnaire designed for this analysis. The following oral mucosa subjective complaints were included: pain, paraesthesia, burning mouth sensation, taste disorders, excessive salivation, halitosis, and dryness of the oral mucosa. The most commonly reported subjective oral complaint in the examined patients was xerostomia, which was found in 92% of patients during the second visit, followed by spontaneous pain in the mouth (55%), burning (36%), and dysgeusia (20%). It occurred significantly more frequently in patients who underwent myeloablative conditioning. Moreover, it was observed that the frequency of complaints increased considerably after the transplantation, reaching a peak intensity during the second week following the procedure. Oral complaints significantly decrease the patients' quality of life during the transplantation and may lead to premature termination of the treatment. As the number of transplantations in patients with acute myeloid leukemia increases, further investigations of oral complaints and symptoms induced by the disease itself and by the therapeutic approaches are required.	es
dc.subject	clec9a	es
dc.subject	dendritic cells	es
dc.subject	tumor microenvironment	es
dc.subject	oral cancer	es
dc.subject	immunotherapy	es
dc.title	Oral complaints in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24647	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412454/