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The genotypes and virulence attributes of C. albicans isolates from oral leukoplakia

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The genotypes and virulence attributes of C. albicans isolates from oral leukoplakia

dc.contributor.author	Weerasekera, Manjula Manoji	es
dc.contributor.author	Wijesinghe, Gayan Kanchana	es
dc.contributor.author	Sampath, Asanga	es
dc.contributor.author	Dilhari, Ayomi	es
dc.contributor.author	Madhumal, Thilina	es
dc.contributor.author	Dilrukshi, Rasika	es
dc.contributor.author	Willaddara, Rajitha	es
dc.contributor.author	Karunathilaka, Sunil	es
dc.contributor.author	Gunasekara, Chinthika	es
dc.contributor.author	Fernando, Neluka	es
dc.contributor.author	Samaranayake, Lakshman P.	es
dc.date.accessioned	2023-06-16T08:36:45Z
dc.date.available	2023-06-16T08:36:45Z
dc.date.issued	2021	es
dc.identifier.citation	Weerasekera, MM., Wijesinghe, GK., Sampath, A., Dilhari, A., Madhumal, T., Dilrukshi, R., Willaddara, R., Karunathilaka, S., Gunasekara, C., Fernando, N., & Samaranayake, N. (2021). The genotypes and virulence attributes of C. albicans isolates from oral leukoplakia. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e786-e794). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24748	es
dc.identifier.uri	https://hdl.handle.net/10550/88087
dc.description.abstract	There is a debate as to whether some types of oral leucoplakias (OL) are caused by Candida species, and whether they contribute to the malignant transformation, associated with a minority of such lesions. As no detailed population analysis of yeast isolates from OL is available, we evaluated the virulence attributes, and genotypes of 35 C. albicans from OL, and compared their genotypes with 18 oral isolates from healthy individuals. The virulence traits evaluated were esterase, phospholipase, proteinase, haemolysin and coagulase production, and phenotypic switching activity, and yeast adherence and biofilm formation. DNA from OL and control yeasts were evaluated for A, B or C genotype status. Phospholipase, proteinase, and coagulase activity and biofilm formation was observed in 80%, 66%, 97 % and 77 % of the isolates, respectively. Phenotypic switching was detected in 8.6%, while heamolytic, and esterase activity and adherence were noted in all isolates. The genotype A was predominant amongst both the OL and control groups. Due to the small sample size of our study a larger investigation to define the role of candidal virulent attributes in the pathogenicity of OL is warranted, and the current data should serve as a basis until then.	es
dc.subject	oral cancer	es
dc.subject	diagnostic delay	es
dc.subject	patient education	es
dc.subject	internet	es
dc.subject	audio-visual resources	es
dc.subject	spanish	es
dc.title	The genotypes and virulence attributes of C. albicans isolates from oral leukoplakia	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24748	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601635/