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Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis

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Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis

dc.contributor.author	Macedo, Nayara	es
dc.contributor.author	Baggio, Gabriela	es
dc.contributor.author	Henn, Indiara	es
dc.contributor.author	Santos, Juliane	es
dc.contributor.author	Corrêa, Gefter Thiago Batista	es
dc.contributor.author	Ignácio, Sérgio-Aparecido	es
dc.contributor.author	Souza, Paulo	es
dc.contributor.author	Azevedo-Alanis, Luciana Reis	es
dc.date.accessioned	2023-06-16T08:36:48Z
dc.date.available	2023-06-16T08:36:48Z
dc.date.issued	2022	es
dc.identifier.citation	Macedo, N., Baggio, G., Henn, I., Santos, J., Batista, T., Ignácio, S., Souza, P., & Azevedo-Alanis, L. (2022). Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e265-e273). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25140	es
dc.identifier.uri	https://hdl.handle.net/10550/88125
dc.description.abstract	New prevention strategies have been advocated to control the progression of HIV/AIDS, such as preexposure prophylaxis (PrEP). The aim of this study is to evaluate the potential changes in the oral and salivary conditions of HIV-uninfected subjects using PrEP. Subjects were evaluated before beginning the medication (T0), at the first follow-up (T1), and at the second follow-up (T2). Xerostomia, presence of untreated cavitated caries, oral hygiene habits, taste, gingival and plaque index, stimulated salivary flow rate (SSFR), and salivary concentrations of calcium, glucose, urea, and total proteins were evaluated. Data obtained were analyzed using statistical tests (p<0.05). Forty-seven participants (41 men; 6 women) were evaluated at T0. Thirty (28 men; 2 women) and 17 men were reassessed at T1 and T2, respectively. There was no difference between the SSFR and oral and salivary conditions between T0, T1, and T2 (p>0.05), except for the salivary calcium concentration, that increased at T2 compared to T1 (p=0.02). There was significant difference between taste and xerostomia at T1 (p=0.017), and the need to drink to swallow at T2 (p=0.015). There was significant correlation between the reported amount of saliva and taste (p=0.039, r=-0.378) at T1. The prolonged use of PrEP seems to be associated with reports of dry mouth and worsening of taste, possibly associated with increased salivary calcium concentration.	es
dc.subject	squamous cell carcinoma of head and neck	es
dc.subject	lip neoplasms	es
dc.subject	mouth neoplasms	es
dc.subject	oropharyngeal neoplasms	es
dc.subject	survival analysis	es
dc.title	Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25140	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054169/