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Connexin 43, Bcl-2, Bax, Ki67, and E-cadherin patterns in oral squamous cell carcinoma and its relationship with GJA1 rs12197797 C/G

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Connexin 43, Bcl-2, Bax, Ki67, and E-cadherin patterns in oral squamous cell carcinoma and its relationship with GJA1 rs12197797 C/G

dc.contributor.author	Segura, Ignacio González	es
dc.contributor.author	Secchi, Dante Gustavo	es
dc.contributor.author	Galíndez, María Fernanda	es
dc.contributor.author	Carrica, Andrés	es
dc.contributor.author	Bologna Molina, Ronell	es
dc.contributor.author	Brunotto, Mabel	es
dc.contributor.author	Centeno, Viviana	es
dc.date.accessioned	2023-06-16T08:36:49Z
dc.date.available	2023-06-16T08:36:49Z
dc.date.issued	2022	es
dc.identifier.citation	Segura, IG., Secchi, DG., Galíndez, MF., Carrica, A., Bologna-Molina, R., Brunotto, M., & Centeno, VA. (2022). Connexin 43, Bcl-2, Bax, Ki67, and E-cadherin patterns in oral squamous cell carcinoma and its relationship with GJA1 rs12197797 C/G. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e366-e374). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25298	es
dc.identifier.uri	https://hdl.handle.net/10550/88136
dc.description.abstract	To our knowledge, there is no useful and accurate prognostic biomarker or biomarkers for patients with oral squamous cell carcinoma (OSCC), a tumor with uncertain biological behavior, and unpredicTable clinical progress. The purposes of this study were: a) to determine the expresión profile of Connexin 43, Bcl-2, Bax, E-cadherin, and Ki67 in patients with OSCC; b) identify the GJCA1 rs12197797 genotypic composition. A cross-sectional study using genomic DNA and biopsy samples extracted from the oral mucosa with/without OSCC, older than 18 years, both genders, attended at Facultad de Odontología, Universidad Nacional Córdoba. Immunostaining for Cx43, Bcl-2, Bax, E-cadherin, and Ki67 and genotyping GJA1 rs12197797 by RFLP were performed. Odds Ratio (95% CI), Spearman Coefficient were estimated. Mann-Whitney test was applied to analyze immunostaining between controls/cases (p <0.05 was set for statistical significance). GG (mutant) was the most frequent genotype in patients with OSCC diagnosis (53.2%) in relation to CC ?healthy? genotype (p=0.00487; OR=7.33; CI95% [1.1-54.7]). And, the allele G (mutant) had a presence in 75.5% of OSCC patients. However, no significant association was observed between alleles C/G and diagnosis (p=0.0565). The heterozygous genotype was the most frequent in the patients of both groups Cx43 and E-cadherin markers were lower in OSCCs in relation to controls. Ki67 and Bcl-2 immunolabeling were high on OSCC, and Bax immunomarker was diminished in OSCC. We hypothesized that the oral epithelium losses Connexin 43 and E-cadherin in the membrane, which modifies cell differentiation. The Ki67 and Bcl2 overexpression would increase the cell density in the tissue, by promoting proliferation and decreasing apoptosis. And, this study shows evidence that patients who carry on allele G of GJA1rs12197797 could be at risk of developing OSCC.	es
dc.subject	endoscope	es
dc.subject	cracks	es
dc.subject	gaps	es
dc.subject	opaque dentin	es
dc.subject	periapical surgery	es
dc.title	Connexin 43, Bcl-2, Bax, Ki67, and E-cadherin patterns in oral squamous cell carcinoma and its relationship with GJA1 rs12197797 C/G	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25298	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271350/