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The value of Phosphohistone H3 as a cell proliferation marker in oral squamous cell carcinoma. A comparative study with Ki-67 and the mitotic activity index

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The value of Phosphohistone H3 as a cell proliferation marker in oral squamous cell carcinoma. A comparative study with Ki-67 and the mitotic activity index

dc.contributor.author	Tancredi-Cueto, Natalia	es
dc.contributor.author	Vigil, Gabriela	es
dc.contributor.author	Bologna Molina, Ronell	es
dc.contributor.author	Beovide?Cortegoso, Verónica	es
dc.date.accessioned	2023-06-16T08:36:50Z
dc.date.available	2023-06-16T08:36:50Z
dc.date.issued	2022	es
dc.identifier.citation	Tancredi-Cueto, N., Vigil-Bastitta, G., Bologna-Molina, R., & Beovide‑Cortegoso, V. (2022). The value of Phosphohistone H3 as a cell proliferation marker in oral squamous cell carcinoma. A comparative study with Ki-67 and the mitotic activity index. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e444-e451). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25420	es
dc.identifier.uri	https://hdl.handle.net/10550/88142
dc.description.abstract	The Phosphohistone H3 (PHH3) antibody is recognized as a biomarker of cell proliferation, specific for cells in mitosis, of prognostic value in different malignant neoplasms, however it has been poorly studied in oral squamous cell carcinoma (OSCC). The main objective of this study was to evaluate the immunoexpression of the PHH3 in the OSCC, through the correlation with the immunoexpression of Ki-67, the mitotic activity index (MAI), histological grading, clinical-morphological parameters and the rate of survival. The study sample consisted of 62 cases of OSCC diagnosed in the Pathological Anatomy Laboratory of the Faculty of Dentistry, University of the Republic (Uruguay). In each of them, an immunohistochemical technique was performed for Ki-67 and PHH3 (serine 10) antibodies. Image J software was used for the MAI and biomarker quantification, defining the percentage of positivity and mitotic Figures per 1000 tumor cells. a significant association was obtained between the expression of PHH3 (p 0.016) and MAI (p 0.031) with survival time. However, no similar relationship was found with Ki-67 (p 0.295). Although it was confirmed a statistical association between histological grade and Ki-67 immunoexpression (p 0.004), PHH3 did not show a similar relationship (p 0.564). It was confirmed the role of the PHH3 antibody as a biomarker of mitotic Figures in OSCC and as a potential marker of cell proliferation. It is noteworthy that this is one of the first works that evaluates a possible relationship between the expression of this antibody and survival in OSCC.	es
dc.subject	oral mucositis	es
dc.subject	erythromycin	es
dc.subject	inflammation	es
dc.subject	immunomodulation	es
dc.subject	oxidative stress	es
dc.title	The value of Phosphohistone H3 as a cell proliferation marker in oral squamous cell carcinoma. A comparative study with Ki-67 and the mitotic activity index	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25420	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445610/