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Peripheral ossifying fibroma:a 20-year retrospective study with focus on clinical and morphological features

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Peripheral ossifying fibroma:a 20-year retrospective study with focus on clinical and morphological features

dc.contributor.author	Cavalcante, Israel Leal	es
dc.contributor.author	Barros, Caio-César-da Silva	es
dc.contributor.author	Cruz, Vitória Maria Sousa	es
dc.contributor.author	Cunha, John Lennon Silva	es
dc.contributor.author	Leão, Lara Cunha Carneiro	es
dc.contributor.author	Ribeiro, Renata Roque	es
dc.contributor.author	Turatti, Eveline	es
dc.contributor.author	Andrade, Bruno Augusto Benevenuto de	es
dc.contributor.author	Cavalcante, Roberta Barroso	es
dc.date.accessioned	2023-06-16T08:36:50Z
dc.date.available	2023-06-16T08:36:50Z
dc.date.issued	2022	es
dc.identifier.citation	Cavalcante, IL., Barros, CC., Cruz, VM., Cunha, JL., Leão, LC., Ribeiro, RR., Turatti, E., Andrade, BA., & Cavalcante, RB. (2022). Peripheral ossifying fibroma: A 20-year retrospective study with focus on clinical and morphological features. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e460-e467). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25454	es
dc.identifier.uri	https://hdl.handle.net/10550/88144
dc.description.abstract	Peripheral Ossifying Fibroma (POF) is a reactive hyperplastic lesion that exclusively occurs in the gingiva and is characterized by the deposition of dystrophic calcification, cementum-like tissue, and immature and mature bone within the connective tissue. The objective of the present study was to perform a retrospective analysis of clinicopathologic features of POF. Clinical and histopathological data were obtained from biopsy records and histopathological reports from a Brazilian reference service in Oral Pathology (1999 - 2020). Morphological analysis was performed to evaluate features related to the mesenchymal component, inflammatory infiltrate, ulceration, and mineralized tissue. A total of 270 POFs were diagnosed during the study period. A higher frequency was observed in females (71.9%) between the third (22.9%) and fourth (23.3%) decades of life. The anterior upper gingiva (29.1%) was the most affected region. Mature (86.7%) and immature (52.6%) bone tissue were the most frequent. There was a significant association between immature bone deposition and lesions with size ? 1.7 cm (p = 0.041); immature bone and cement-like tissue deposition with an evolution time ? 16 months (p < 0.001); deposition of immature bone and mesenchymal hypercellularization (p < 0.001); deposition of dystrophic calcification and the presence of ulceration (p < 0.001). The clinical characteristics corroborate the findings in the literature. The heterogeneous distribution and quantity of mineralized tissues found in the analyzed cases support the theory that the different mineralized tissues constitute a spectrum of clinical maturation of POF.	es
dc.subject	l-prf	es
dc.subject	bone healing	es
dc.subject	socket preservation	es
dc.title	Peripheral ossifying fibroma:a 20-year retrospective study with focus on clinical and morphological features	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25454	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445604/