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Do Intestinal Unicellular Parasites Have a Role in the Inflammatory and Redox Status among the Severely Obese?

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Do Intestinal Unicellular Parasites Have a Role in the Inflammatory and Redox Status among the Severely Obese?

dc.contributor.author	Caudet, Jana
dc.contributor.author	Trelis Villanueva, María
dc.contributor.author	Cifre, Susana
dc.contributor.author	Tapia-Veloz, Gabriela
dc.contributor.author	Soriano del Castillo, José Miguel
dc.contributor.author	Rodrigo Nicolás, Regina
dc.contributor.author	Merino Torres, Juan Francisco
dc.date.accessioned	2023-06-20T13:22:03Z
dc.date.available	2023-06-20T13:22:03Z
dc.date.issued	2022
dc.identifier.citation	Caudet, Jana Trelis Villanueva, María Cifre, Susana Tapia-Veloz, Gabriela Soriano del Castillo, José Miguel Rodrigo Nicolás, Regina Merino Torres, Juan Francisco 2022 Do Intestinal Unicellular Parasites Have a Role in the Inflammatory and Redox Status among the Severely Obese? Antioxidants 11 11 2090
dc.identifier.uri	https://hdl.handle.net/10550/88363
dc.description.abstract	The diagnosis of obesity comprises subjects with totally different phenotypes and metabolic profiles. Systemic inflammation and oxidative stress derived from the white adipose tissue are suggested as the link between this disease and the development of insulin resistance and metabolic comorbidities. The presence of unicellular eukaryotic parasites colonizing the human gut ecosystem is a common circumstance, and yet their influence on the inflammatory and redox status of the obese host has not been assessed. Herein, a set of inflammatory and redox biomarkers were assessed together with a parasitological analysis of 97 severely obese subjects. Information was also collected on insulin resistance and on the antioxidant composition of the diet. The global prevalence of intestinal unicellular parasites was 49.5%, with Blastocystis sp. the most prevalent protozoan found (42.3%). Colonized subjects displayed a higher total antioxidant capacity and a trend towards higher extracellular superoxide dismutase activity, regardless of their insulin resistance status, along with lower reduced glutathione/oxidized glutathione (GSH/GSSG) ratios in plasma in the insulin-resistant subgroup. No changes in malondialdehyde levels, or in inflammatory cytokines in plasma, were found in regard to the colonization status. In conclusion, enteric eukaryotic unicellular parasites may play an important role in modulating the antioxidant defenses of an obese host, thus could have beneficial effects with respect to the development of systemic metabolic disorders.
dc.language.iso	eng
dc.relation.ispartof	Antioxidants, 2022, vol. 11, num. 11, p. 2090
dc.subject	Obesitat
dc.subject	Antioxidants
dc.title	Do Intestinal Unicellular Parasites Have a Role in the Inflammatory and Redox Status among the Severely Obese?
dc.type	journal article
dc.date.updated	2023-06-20T13:22:03Z
dc.identifier.doi	10.3390/antiox11112090
dc.identifier.idgrec	160618
dc.rights.accessRights	open access