COVID-19 pandemic-related confnement may be a fruitful opportunity to use individ ual resources to deal with it or experience psychological functioning changes. This study aimed to analyze the evolution of diferent psychological variables during the frst coro navirus wave to identify the diferent psychological response clusters, as well as to keep a follow-up on the changes among these clusters. The sample included 459 Spanish residents (77.8% female, Mage=35.21 years, SDage=13.00). Participants completed several online self-reported questionnaires to assess positive functioning variables (MLQ, Steger et al. in J Loss Trauma 13(6):511–527, 2006. 10.1080/15325020802173660; GQ-6, McCullough et al. in J Person Soc Psychol 82:112–127, 2002. 10.1037/0022-3514.82.1.112; CD-RISC, Campbell-Sills and Stein in J Traum Stress 20(6):1019–1028, 2007. 10.1002/jts.20271; CLS-H, Chiesi et al. in BMC Psychol 8(1):1–9, 2020. 10.1186/s40359-020-0386-9; SWLS; Diener et al. in J Person Assess, 49(1), 71–75, 1985), emotional distress (PHQ-2, Kroenke et al. in Med Care 41(11):1284–1292, 2003. 10.1097/01.MLR.0000093487.78664.3C; GAD-2, Kroenke et al. in Ann Internal Med 146(5):317–325, 2007. 10.7326/0003-4819- 146-5-200703060-00004; PANAS, Watson et al. in J Person Soc Psychol 47:1063–1070, 1988; Perceived Stress, ad hoc), and post-traumatic growth (PTGI-SF; Cann et al. in Anxiety Stress Coping 23(2):127–137, 2010. 10.1080/10615800903094273), four times throughout the 3 months of the confnement. Linear mixed models showed that the scores on positive functioning variables worsened from the beginning of the confnement, while emotional distress and personal strength improved by the end of the state of alarm. Cluster ing analyses revealed four diferent patterns of psychological response: “Survival”, “Resur gent”, “Resilient”, and “Thriving” individuals. Four diferent profles were identifed during mandatory confnement and most participants remained in the same cluster. The “Resilient” cluster gathered the largest number of individuals (30–37%). We conclude that both the heterogeneity of psychological profles and analysis of positive functioning varia bles, emotional distress, and post-traumatic growth must be considered to better understand the response to prolonged adverse situations.