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Enhancing nutrient recovery and bioactive compound extraction from spirulina through supercritical fluid extraction : implications for SH-SY5Y cell viability

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Enhancing nutrient recovery and bioactive compound extraction from spirulina through supercritical fluid extraction : implications for SH-SY5Y cell viability

dc.contributor.author	Martí Quijal, Francisco Juan
dc.contributor.author	Pallarés Barrachina, Noelia
dc.contributor.author	Dawidowicz, Katarzyna
dc.contributor.author	Ruiz Leal, María José
dc.contributor.author	Barba Orellana, Francisco José
dc.date.accessioned	2023-09-05T15:51:02Z
dc.date.available	2023-09-05T15:51:02Z
dc.date.issued	2023
dc.identifier.citation	Martí Quijal, Francisco Juan Pallarés Barrachina, Noelia Dawidowicz, Katarzyna Ruiz Leal, María José Barba Orellana, Francisco José 2023 Enhancing nutrient recovery and bioactive compound extraction from spirulina through supercritical fluid extraction : implications for SH-SY5Y cell viability Foods 12 2509
dc.identifier.uri	https://hdl.handle.net/10550/89079
dc.description.abstract	This work explores the efficiency of supercritical fluid extraction (SFE) to recover minerals, pigments, and antioxidant compounds from the spirulina microalgae. Moreover, the fatty acids and phenolic profiles of the extracts obtained were also investigated, and the effect of the extracts on SH-SY5Y cell viability was tested. The extraction of phycocyanin was improved by SFE compared to conventional extraction, from 2.838 ± 0.081 mg/g dry matter (DM) (control) to 6.438 ± 0.411 mg/g DM (SFE). SFE treatment also improved chlorophyll a and carotenoid recoveries increasing from 5.612 ± 0.547 to 8.645 ± 0.857 mg/g DM and from 0.447 ± 0.096 to 0.651 ± 0.120 mg/g DM, respectively. Regarding minerals, the SFE improved Mg recovery with 77% more than the control extraction. Moreover, palmitoleic, stearic, γ-linolenic, eicosadienoic and eicosatrienoic acids recovery was improved by SFE. Phenolic profiles were identified via triple-TOF-LC-MS-MS. Considering heavy metals, a higher rate of Pb extraction was observed for the SFE extract, while no significant differences were observed for Hg between both extractions. Finally, SFE extract improved cell viability compared to the control extract. Thus, SFE constitutes an interesting tool to sustainably extract high-added-value compounds; however, potential contaminants such as Pb need to be controlled in the resulting extracts.
dc.language.iso	eng
dc.relation.ispartof	Foods, 2023, vol. 12, p. 2509
dc.subject	Algues
dc.subject	Antioxidants
dc.title	Enhancing nutrient recovery and bioactive compound extraction from spirulina through supercritical fluid extraction : implications for SH-SY5Y cell viability
dc.type	journal article
dc.date.updated	2023-09-05T15:51:03Z
dc.identifier.doi	10.3390/foods12132509
dc.identifier.idgrec	160841
dc.rights.accessRights	open access