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The link between anterior scleral thickness, corneal biomechanical response and ocular parameters

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The link between anterior scleral thickness, corneal biomechanical response and ocular parameters

dc.contributor.author	Burguera Giménez, Neus
dc.contributor.author	Díez Ajenjo, María Amparo
dc.contributor.author	Burguera Giménez, Noemí
dc.contributor.author	Luque Cobija, María Josefa
dc.contributor.author	Peris Martínez, Cristina
dc.date.accessioned	2023-11-04T12:18:32Z
dc.date.available	2023-11-04T12:18:32Z
dc.date.issued	2022
dc.identifier.uri	https://hdl.handle.net/10550/90956
dc.description.abstract	Abstract Purpose: to assess anterior scleral thickness (AST) across diverse scleral meridians and to evaluate the relationship with corneal biomechanical response and several ocular parameters. Methods: This prospective non-randomized study comprised 50 eyes of 50 patients (mean age, 29.02 ± 9.48 years). Anterior scleral thickness was measured meridionally at three scleral locations (1, 2, and 3 mm posterior to the scleral spur) using swept-source optical coherence tomography. A multivariate model was created to associate AST with several ocular parameters. Principal component analysis (PCA) was used to reduce linearly the dimensionality of seven biomechanical input metrics to two significant components, C1 and C2. Two multivariate analyses were performed to associate C1 and C2 with AST and several ocular parameters. Results: AST was thickest in the inferior (581 ± 52 µm) and thinnest in the superior meridian (441 ± 42 µm) when compared to all meridians (p<0.001), and similar in the nasal (529 ± 53 µm) and temporal (511 ± 59 µm) meridians (p>0.05). The sclera exhibited the thinnest point 2 mm posterior to the scleral spur (p<0.001). The AST was significantly linked with axial length, central corneal thickness, and intraocular pressure (p<0.001). The PCA showed that C1 accounts for 53.84% whereas C2 for the 16.51% of the total variance in the original variables. The C1 model was significantly associated with AST along all meridians (p<0.001). The partial correlation was moderate in the nasal (r= -0.36, p<0.001) and inferior (r= -0.26, p=0.004) meridians whereas weak in the temporal (r= -0.14, p=0.05) and superior (r= -0.15, p=0.05) meridians. Conclusions: The relationship between the new biomechanical component and the AST provides the first evidence of the association of AST with the corneal response parameters which should be considered in corneal response interpretation. Tissue thickness varied significantly among meridians supporting the asymmetrical expansion of the ocular globe. The AST was associated with several ocular parameters.
dc.language.iso	eng
dc.relation.ispartof	Ophthalmic Research, 2022
dc.source	Burguera Giménez, Neus Díez Ajenjo, María Amparo Burguera Giménez, Noemí Luque Cobija, María Josefa Peris Martínez, Cristina 2022 The link between anterior scleral thickness, corneal biomechanical response and ocular parameters Ophthalmic Research
dc.subject	Ulls Malalties i defectes
dc.title	The link between anterior scleral thickness, corneal biomechanical response and ocular parameters
dc.type	journal article
dc.date.updated	2023-11-04T12:18:32Z
dc.identifier.doi	10.1159/000525584
dc.identifier.idgrec	155553
dc.rights.accessRights	open access