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Evaluation and synthesis of 7-arylhydroxymethyltriazolopyridines as potential cardiovascular agents

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Evaluation and synthesis of 7-arylhydroxymethyltriazolopyridines as potential cardiovascular agents

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dc.contributor.author	Abarca González, Belén
dc.contributor.author	Ballesteros Campos, Rafael
dc.contributor.author	Elmasnaouy, Mostafá
dc.contributor.author	D'Ocon Navaza, María Pilar
dc.contributor.author	Ivorra Insa, María Dolores
dc.contributor.author	Valiente Bautista, Miguel
dc.date.accessioned	2010-06-08T10:32:58Z
dc.date.available	2010-06-08T10:32:58Z
dc.date.issued	2002
dc.identifier.citation	ABARCA GONZALEZ, Belen ; Ballesteros Campos,Rafael ; Elmasnaouy, Mostafá ; D’Ocón, Pilar ; Ivorra Insa, Maria Dolores ; Valiente Bautista, Miguel, 2002, Evaluation and synthesis of 7-arylhydroxymethyltriazolopyridines as potential cardiovascular agents, Arkivoc, vol. 2002, no. X, p. 9-13	en
dc.identifier.uri	http://hdl.handle.net/10550/12904
dc.description.abstract	7-Arylhydroxymethyltriazolopyridines 3a-c and 4a-d were synthesized by regioselective lithiation of [1,2,3]triazolo[1,5-a]pyridines 1 and 2 and subsequent trapping of the 7-lithioderivatives formed using aryl aldehydes as electrophiles. The structural relationship between compounds 3a-c and 4a-d and arylethanolamines suggested their consideration as potential cardiovascular agents. A preliminary evaluation as vascular smooth muscle relaxants was carried out. These compounds did not act as α1-adrenoceptor antagonists and were unable to block calcium entry through voltage-dependent calcium channels.	en
dc.language.iso	en	en
dc.subject	Triazolopyridines ; Lithiation reaction ; α1-adrenoceptor antagonism ; Calcium channels blockade	en
dc.title	Evaluation and synthesis of 7-arylhydroxymethyltriazolopyridines as potential cardiovascular agents	en
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::QUÍMICA	en
dc.subject.unesco	UNESCO::QUÍMICA::Química orgánica	en
dc.identifier.idgrec	003661	en
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://www.arkat-usa.org/get-file/19233/	en