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Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth

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Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth

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dc.contributor.author Vilar, Marçal
dc.contributor.author Shirazi Fard, Shahrzad
dc.contributor.author Kele, Julianna
dc.contributor.author Paratcha, Gustavo
dc.contributor.author Ledda, Fernanda
dc.date.accessioned 2010-07-13T07:59:49Z
dc.date.available 2010-07-13T07:59:49Z
dc.date.issued 2010
dc.identifier.citation Shirazi Fard, S; Kele, J; Vilar, Marçal; Paratcha, G; Ledda, F. Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth. En PLoS One. 2010; 5(3): e9647 en
dc.identifier.uri http://hdl.handle.net/10550/15984
dc.description.abstract Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases. However, the molecular mechanisms through which NGF regulates cytoskeletal changes and neurite outgrowth are not totally understood. In this work, we identify the Rac1-specific guanine exchange factor (GEF) Tiam1 as a novel mediator of NGF/TrkA-dependent neurite elongation. In particular, we report that knockdown of Tiam1 causes a significant reduction in Rac1 activity and neurite outgrowth induced by NGF. Physical interaction between Tiam1 and active Ras (Ras-GTP), but not tyrosine phosphorylation of Tiam1, plays a central role in Rac1 activation by NGF. In addition, our findings indicate that Ras is required to associate Tiam1 with Rac1 and promote Rac1 activation upon NGF stimulation. Taken together, these findings define a novel molecular mechanism through which Tiam1 mediates TrkA signaling and neurite outgrowth induced by NGF. en
dc.language.iso en en
dc.subject Tiam1; Nerve growth factor (NGF) en
dc.title Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth en
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS DE LA VIDA::Biología molecular en
dc.identifier.doi 10.1371/journal.pone.0009647 en
dc.type.hasVersion VoR es_ES
dc.identifier.url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841637/pdf/pone.0009647.pdf en

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