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Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia

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Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia

dc.contributor.author	Jantus Lewintre, Eloisa
dc.contributor.author	Reinoso Martín, Cristina
dc.contributor.author	García Ballesteros, Carlos
dc.contributor.author	Montaner González, David
dc.contributor.author	Farrás Rivera, Rosa
dc.contributor.author	Mayans, José Ramón
dc.contributor.author	García-Conde Bru, Javier
dc.date.accessioned	2010-07-28T11:41:00Z
dc.date.available	2010-07-28T11:41:00Z
dc.date.issued	2008
dc.identifier.citation	JANTUS LEWINTRE, Eloisa ; Reinoso Martín, Cristina ; García Ballesteros, Carlos ; Montaner Gonzalez, David ; Farrás Rivera, Rosa ; Mayans, José Ramón ; García-Conde, Javier, 2008, Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia, Haematologica, vol. 94, no. 2, p. 280-284	en
dc.identifier.uri	http://hdl.handle.net/10550/16692
dc.description.abstract	Chronic lymphocytic leukemia is an adult-onset leukemia with a heterogeneous clinical behavior. When chronic lymphocytic leukemia cases were divided on the basis of IgVH mutational status, widely differing clinical courses were revealed. Since IgVH sequencing is difficult to perform in a routine diagnostic laboratory, finding a surrogate for IgVH mutational status seems an important priority. In the present study, we proposed the use of Cryptochrome- 1 as a new prognostic marker in early-stage chronic lymphocytic leukemia. Seventy patients (Binet stage A, without treatment) were included in the study. We correlated Cryptochrome-1 mRNA with well established prognostic markers such as IgVH mutations, ZAP70, LPL or CD38 expression and chromosomal abnormalities. High Cryptochrome-1 expression correlated with IgVH unmutated samples. In addition, Cryptochrome-1 was a valuable predictor of disease progression in early stage chronic lymphocytic leukemia, therefore it can be introduced in clinical practice with the advantage of a simplified method of quantification.	en
dc.language.iso	en	en
dc.subject	Cryptochrome-1 ; Prognostic marker ; Chronic lymphocytic leukemia ; ZAP70, LPL, IgVH	en
dc.title	Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia	en
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	en
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS ::Patología::Oncología	en
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS ::Patología::Hematología
dc.identifier.doi	10.3324/haematol.13052	en
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://www.haematologica.org/cgi/reprint/94/2/280	en