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Influence of the i/d polymorphism of the angiotensin-converting enzyme gene on the outcome of microalbuminuria in essential hypertension

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Influence of the i/d polymorphism of the angiotensin-converting enzyme gene on the outcome of microalbuminuria in essential hypertension

dc.contributor.author	Redón i Más, Josep
dc.contributor.author	Chaves Martínez, Felipe Javier
dc.contributor.author	Liao, Youlian
dc.contributor.author	Pascual Izuel, José María
dc.contributor.author	Rovira, Eduardo
dc.contributor.author	Armengod González, María Eugenia
dc.contributor.author	Cooper, Richard
dc.date.accessioned	2010-07-30T11:12:58Z
dc.date.available	2010-07-30T11:12:58Z
dc.date.issued	2000
dc.identifier.citation	REDON MAS, Josep ; Chaves Martinez, Felipe Javier ; Liao, Youlian ; Pascual Izuel, Jose Maria ; Rovira, Eduardo ; Armengod, Maria Eugenia ; Cooper, Richard S., 2000, Influence of the I/D polymorphism of the angiotensin-converting enzyme gene on the outcome of microalbuminuria in essential hypertension, Hypertension, vol. 35, no. 1, p. 490-495	en
dc.identifier.uri	http://hdl.handle.net/10550/16754
dc.description.abstract	The objective of the present study was to analyze the influence of the I/D polymorphism of the ACE gene on the outcome of microalbuminuria in essential hypertensive patients who were receiving antihypertensive treatment. One hundred thirty-six essential hypertensive patients who were <50 years old and had never previously received treatment with antihypertensive drugs were included in the study. During a 3-year period, patients received nonpharmacological treatment consisting of moderate salt restriction and a low-calorie diet they were obese, with or without a regimen of antihypertensive drugs based on ß-blockers or ACE inhibitors. Hydrochlorothiazide was added when necessary to maintain the blood pressure goal of <135/85 mm Hg. At the beginning of the study and at yearly intervals, systolic and diastolic blood pressures (SBP and DBP, respectively), 24-hour urinary albumin excretion (UAE), renal function, and biochemical profile measurements were made. The insertion/deletion (I/D) polymorphism of the ACE gene was determined through the use of polymerase chain reaction. The variables used in the statistical analysis were the measurements at the start of the study and the increase or decrease detected during the follow-up, estimated as individual specific regression line slope values. At baseline, no differences in blood pressure or UAE values were observed among genotypes. Likewise, the genotype or allele frequency was not significantly different between normoalbuminurics and microalbuminurics. After the 3 treatment years, significant reductions in SBP, DBP, and UAE were found (SBP 151.6±17.3 reduced to 137.2±14.3 mm Hg, P<0.001; DBP 96.6±8.9 reduced to 84.5±9.8 mm Hg, P<0.001; UAE 36.7±71.5 reduced to 28.3±78.6 mg/24 h, P<0.05). The slopes of these parameters over time did not differ significantly among genotypes. The slope of SBP was the main factor related to the slope of logUAE (P<0.003). A significant positive correlation coefficient between the SBP and logUAE slopes was observed for the DD patients (r=0.57, P<0.0001) but was absent in patients carrying the I allele (II r=-0.03, P=NS; I/D r=0.01, P=NS). Follow-up studies should be used to achieve a better understanding of the impact of candidate gene polymorphisms on the development of hypertension-induced organ damage. Assessment of the I/D polymorphism of the ACE gene may identify subjects who require a greatly lowered blood pressure to prevent organ damage and to reduce hypertension-associated complications and death.	en
dc.language.iso	en	en
dc.subject	Hypertension, essential ; Albuminuria ; Genetics ; Angiotensin-converting enzyme gene	en
dc.title	Influence of the i/d polymorphism of the angiotensin-converting enzyme gene on the outcome of microalbuminuria in essential hypertension	en
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	en
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS ::Medicina interna	en
dc.identifier.idgrec	018496	en
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://hyper.ahajournals.org/cgi/reprint/35/1/490	en