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Kinetics of antibodies and antigens in serum of mice experimentally infected with echinostoma caproni (trematoda: echinostomatidae)

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Kinetics of antibodies and antigens in serum of mice experimentally infected with echinostoma caproni (trematoda: echinostomatidae)

dc.contributor.author	Toledo Navarro, Rafael
dc.contributor.author	Espert Fernandez, Ana M.
dc.contributor.author	Muñoz Antoli-Candela, Carla Teresa
dc.contributor.author	Marcilla Díaz, Antonio
dc.contributor.author	Fried, Bernard
dc.contributor.author	Esteban Sanchis, Jose Guillermo
dc.date.accessioned	2010-08-09T10:34:19Z
dc.date.available	2010-08-09T10:34:19Z
dc.date.issued	2005
dc.identifier.citation	TOLEDO NAVARRO, Rafael ; Espert Fernandez, Ana M. ; Muñoz Antoli-Candela, Carla Teresa ; Marcilla Diaz, Antonio ; Fried, Bernard ; Esteban Sanchis, Jose Guillermo, 2005, Kinetics of antibodies and antigens in serum of mice experimentally infected with echinostoma caproni (Trematoda: echinostomatidae), Journal of Parasitology, vol. 91, no. 4, p. 978–980	en
dc.identifier.uri	http://hdl.handle.net/10550/16775
dc.description.abstract	The present study reports on the kinetics of antibodies and antigens in serum of mice experimentally infected with 75 metacercariae of Echinostoma caproni during the first 12 wk postinfection (wpi). Antibody titers in the serum of mice were determined by an indirect enzyme-linked immunosorbent assay (ELISA) using excretory/secretory (ES) antigens of E. caproni. The early detection of antibodies against ES antigens of E. caproni is feasible using indirect ELISA. Mice developed significant antibody responses at 2 wpi, and the values progressively increased until the end of the experiment. This may be related to the intestinal absorption of adult worm antigens that induces humoral responses. The presence of E. caproni circulating antigens was determined by a capture ELISA based on polyclonal rabbit antibodies against ES antigens of E. caproni. High levels of seroantigens in mice were detected by 1–2 wpi, probably because of the local inflammatory responses in mice induced by the adult worms. A drop in circulating antigen levels was observed at 9 wpi, which could reflect changes in the intestinal tissues over the course of the infection.	en
dc.language.iso	en	en
dc.subject	Antibodies ; Antigens ; Echinostoma caproni	en
dc.title	Kinetics of antibodies and antigens in serum of mice experimentally infected with echinostoma caproni (trematoda: echinostomatidae)	en
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS DE LA VIDA	en
dc.subject.unesco	UNESCO::CIENCIAS DE LA VIDA::Biología animal (Zoología) ::Parasitología animal	en
dc.identifier.idgrec	025476	en
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://www.journalofparasitology.org/doi/pdf/10.1645/GE-461R.1	en