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Increased recovery of brain acetylcholinesterase activity in dichlorvos-intoxicated European eels Anguilla anguilla by bath treatment with N-acetylcysteine

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Increased recovery of brain acetylcholinesterase activity in dichlorvos-intoxicated European eels Anguilla anguilla by bath treatment with N-acetylcysteine

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dc.contributor.author Peña Llopis, Samuel
dc.contributor.author Ferrando Rodrigo, Mª Dolores
dc.contributor.author Peña, Juan B.
dc.date.accessioned 2011-08-19T09:13:03Z
dc.date.available 2011-08-19T09:13:03Z
dc.date.issued 2003
dc.identifier.citation PEÑA-LLOPIS, Samuel ; Ferrando Rodrigo, Dolores ; Peña, Juan B., 2003, Increased recovery of brain acetylcholinesterase activity in dichlorvos-intoxicated European eels Anguilla anguilla by bath treatment with N-acetylcysteine, Diseases of aquatic organisms, vol. 55, no. 2, p. 237-245 en
dc.identifier.uri http://hdl.handle.net/10550/20050
dc.description.abstract Organophosphate (OP) pesticides are widely used as antiparasitic chemicals in finfish aquaculture. However, current antidotes cannot be applied to treat intoxicated fish. We showed in previous studies the importance of glutathione (GSH) metabolism in pesticide resistance of the European eel Anguilla anguilla L. The present work studied the effects of the antioxidant and glutathione pro-drug N-acetyl-l-cysteine (NAC) on the recovery of European eels exposed for 96 h to a sublethal concentration (0.17 mg l^-1; 20% of its 96 h LC50) of the OP pesticide dichlorvos (2,2-dichlorovinyl dimethyl phosphate; DDVP). This insecticide and acaricide decreased muscular GSH content and increased oxidised glutathione (GSSG), lowering the GSH:GSSG ratio, which is indicative of a condition of oxidative stress. Acetylcholinesterase (AChE) and glutathione reductase (GR) activities in the brain, which were biomarkers of neurotoxicity and oxidative stress, respectively, were also highly inhibited. Recovery in a 0.5 mM (81.6 mg l^-1) NAC concentration ameliorated muscular GSH depletion, GSH:GSSG ratio, and the inhibition of brain AChE and GR activities. Hence, this is the first evidence of improved recovery of organophosphate-poisoned fish by bath treatments. en
dc.language.iso en en
dc.subject Detoxification ; Organophosphorus pesticide ; Organophosphate poisoning ; Cholinesterase inhibitor ; Oxidative stress ; N-acetyl-l-cysteine ; AChE ; Glutathione metabolism en
dc.title Increased recovery of brain acetylcholinesterase activity in dichlorvos-intoxicated European eels Anguilla anguilla by bath treatment with N-acetylcysteine en
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS DE LA VIDA en
dc.subject.unesco UNESCO::CIENCIAS DE LA VIDA::Biología animal (Zoología) en
dc.identifier.doi 10.3354/dao055237 en
dc.identifier.idgrec 001546 en
dc.type.hasVersion VoR es_ES
dc.identifier.url http://www.int-res.com/articles/dao2003/55/d055p237.pdf en

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