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Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide

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Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide

dc.contributor.author	Víctor González, Víctor Manuel
dc.contributor.author	Nuñez, Cristina
dc.contributor.author	D'Ocon Navaza, María Pilar
dc.contributor.author	Cormac T., Taylor
dc.contributor.author	Esplugues Mota, Juan Vicente
dc.contributor.author	Salvador, Moncada
dc.date.accessioned	2011-08-19T09:15:11Z
dc.date.available	2011-08-19T09:15:11Z
dc.date.issued	2009
dc.identifier.citation	Víctor González, Víctor Manuel; Nuñez, Cristina ; d'Ocon Navaza, Maria Pilar ; Cormac T., Taylor , Esplugues Mota, Juan Vicente ; Salvador, Moncada, 2009, Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide, Circulation Research, vol. 104, no. 10, p. 1178-1183	en
dc.identifier.uri	http://hdl.handle.net/10550/20054
dc.description.abstract	Nitric oxide (NO) decreases cellular oxygen (O2) consumption by competitively inhibiting cytochrome c oxidase. Here, we show that endogenously released endothelial NO, either basal or stimulated, can modulate O2 consumption both throughout the thickness of conductance vessels and in the microcirculation. Furthermore, we have shown that such modulation regulates O2 distribution to the surrounding tissues. We have demonstrated these effects by measuring O2 consumption in blood vessels in a hypoxic chamber and O2 distribution in the microcirculation using the fluorescent oxygen-probe Ru(phen)3^2+. Removal of NO by physical or pharmacological means, or in eNOS^¯/¯ mice, abolishes this regulatory mechanism. Our results indicate that, in addition to its well-known effect on the regulation of vascular tone, endothelial NO plays a major role in facilitating the distribution of O2, an action which is crucial for the adaptation of tissues, including the vessel wall itself, to hypoxia. It is possible that changes in the distribution of O2 throughout the vessel wall may be implicated in the origin of vascular pathologies such as atherosclerosis.	en
dc.language.iso	en	en
dc.subject	Nitric oxide ; Endothelium ; Oxygen consumption	en
dc.title	Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide	en
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	en
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS ::Medicina interna	en
dc.identifier.doi	10.1161/CIRCRESAHA.109.197228	en
dc.identifier.idgrec	051285	en
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://circres.ahajournals.org/cgi/reprint/104/10/1178	en