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Angiotensin II Induces Neutrophil Accumulation In Vivo Through Generation and Release of CXC Chemokines

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Angiotensin II Induces Neutrophil Accumulation In Vivo Through Generation and Release of CXC Chemokines

dc.contributor.author	Abu Nabah, Yafa Naim
dc.contributor.author	Mateo, Teresa
dc.contributor.author	Estellés, Rossana
dc.contributor.author	Mata Roig, Manuel
dc.contributor.author	Zagorski, John
dc.contributor.author	Sarau, Henry
dc.contributor.author	Cortijo Gimeno, Julio
dc.contributor.author	Morcillo Sánchez, Esteban
dc.contributor.author	Jose, Peter J.
dc.contributor.author	Sanz Ferrando, María Jesús
dc.date.accessioned	2011-08-19T09:26:53Z
dc.date.available	2011-08-19T09:26:53Z
dc.date.issued	2004
dc.identifier.citation	ABU NABAH, Yafa Naim ; Mateo, Teresa ; Estellés, Rossana ; Mata Roig, Manuel ; Zagorski, John ; Sarau, Henry ; Cortijo Gimeno, Julio ; Morcillo Sanchez, Esteban Jesus ; Jose, Peter J. ; Sanz Ferrando, Maria Jesus, 2004, Angiotensin II Induces Neutrophil Accumulation In Vivo Through Generation and Release of CXC Chemokines, Circulation, vol. 110, no. 23, p. 3581-3586	en
dc.identifier.uri	http://hdl.handle.net/10550/20060
dc.description.abstract	Background— Angiotensin II (Ang II) is implicated in the development of cardiac ischemic disorders in which prominent neutrophil accumulation occurs. Ang II can be generated intravascularly by the renin-angiotensin system or extravascularly by mast cell chymase. In this study, we characterized the ability of Ang II to induce neutrophil accumulation. Methods and Results— Intraperitoneal administration of Ang II (1 nmol/L) induced significant neutrophil recruitment within 4 hours (13.3±2.3x106 neutrophils per rat versus 0.7±0.5x106 in control animals), which disappeared by 24 hours. Maximal levels of CXC chemokines were detected 1 hour after Ang II injection (577±224 pmol/L cytokine-inducible neutrophil chemoattractant [CINC]/keratinocyte-derived chemokine [KC] versus 5±3, and 281±120 pmol/L macrophage inflammatory protein [MIP-2] versus 14±6). Intravital microscopy within the rat mesenteric microcirculation showed that the short-term (30 to 60 minutes) leukocyte–endothelial cell interactions induced by Ang II were attenuated by an anti-rat CINC/KC antibody and nearly abolished by the CXCR2 antagonist SB-517785-M. In human umbilical vein endothelial cells (HUVECs) or human pulmonary artery media in culture, Ang II induced interleukin (IL)-8 mRNA expression at 1, 4, and 24 hours and the release of IL-8 at 4 hours through interaction with Ang II type 1 receptors. When HUVECs were pretreated with IL-1 for 24 hours to promote IL-8 storage in Weibel-Palade bodies, the Ang II–induced IL-8 release was more rapid and of greater magnitude. Conclusions— Ang II provokes rapid neutrophil recruitment, mediated through the release of CXC chemokines such as CINC/KC and MIP-2 in rats and IL-8 in humans, and may contribute to the infiltration of neutrophils observed in acute myocardial infarction.	en
dc.language.iso	en	en
dc.subject	Angiotensin ; Interleukins ; Cells ; Endothelium ; Inflammation	en
dc.title	Angiotensin II Induces Neutrophil Accumulation In Vivo Through Generation and Release of CXC Chemokines	en
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	en
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS ::Medicina interna	en
dc.identifier.doi	10.1161/01.CIR.0000148824.93600.F3	en
dc.identifier.idgrec	015234	en
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://circ.ahajournals.org/cgi/reprint/110/23/3581	en