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Contractile responses of human thyroid arteries to vasopressin

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Contractile responses of human thyroid arteries to vasopressin

dc.contributor.author	Vila Salinas, José María
dc.contributor.author	Aldasoro Celaya, Martín
dc.contributor.author	Segarra Irles, Gloria Vicenta
dc.contributor.author	Martínez León, Juan Bautista
dc.contributor.author	Mauricio Aviñó, María Dolores
dc.contributor.author	Lluch López, Salvador
dc.contributor.author	Medina Bessó, Pascual
dc.date.accessioned	2013-11-18T13:01:45Z
dc.date.available	2013-11-18T13:01:45Z
dc.date.issued	2013
dc.identifier.citation	Vila Salinas, José María Aldasoro Celaya, Martín Segarra Irles, Gloria Vicenta Martínez León, Juan B Mauricio Aviñó, María Dolores Lluch López, Salvador Medina Bessó, Pascual 2013 Contractile responses of human thyroid arteries to vasopressin Life Sciences 93 525 529
dc.identifier.uri	http://hdl.handle.net/10550/31116
dc.description.abstract	Aims: In the present study we investigated the intervention of nitric oxide and prostacyclin in the responses to vasopressin of isolated thyroid arteries obtained from multi-organ donors. Main methods: Paired artery rings from glandular branches of the superior thyroid artery, one normal and the other deendothelised, were mounted in organ baths for isometric recording of tension. Concentration-response curves to vasopressin were determined in the absence and in the presence of either the vasopressin V1 receptor antagonist d(CH2)5Tyr(Me)AVP (10−8 M), the nitric oxide synthase inhibitor NG-monomethyl-Larginine (L-NMMA, 10−4 M), or the inhibitor of prostaglandins indomethacin (10−6 M). Key findings: In artery rings under resting tension, vasopressin produced concentration-dependent, endotheliumindependent contractions. The vasopressin V1 receptor antagonist d(CH2)5Tyr(Me)AVP (10−8 M) displaced the control curve to vasopressin 19-fold to the right in a parallelmanner. The contractile response to vasopressinwas unaffected by L-NMMA or by indomethacin. Significance: Vasopressin causes constriction of human thyroid arteries by stimulation of V1 vasopressin receptors located on smooth muscle cells. These effects are not linked to the presence of an intact endothelium or to the release of nitric oxide or prostaglandins. The constriction of thyroid arteries may be particularly relevant in certain pathophysiological circumstances in which vasopressin is released in amounts that could interfere with the blood supply to the thyroid gland.
dc.relation.ispartof	Life Sciences, 2013, vol. 93, p. 525-529
dc.subject	Tiroide Malalties
dc.title	Contractile responses of human thyroid arteries to vasopressin
dc.type	journal article	es_ES
dc.date.updated	2013-11-18T13:01:45Z
dc.identifier.idgrec	091795
dc.rights.accessRights	open access	es_ES