Modulation of adrenergic responses of human vas deferens by K+ channel inhibitors
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Medina Bessó, Pascual; Segarra Irles, Gloria Vicenta; Mauricio Aviñó, María Dolores; Vila Salinas, José María; Chuan Nuez, Pascual; Lluch López, Salvador
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Aquest document és un/a article, creat/da en: 2010
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The results suggest that charybdotoxin-sensitive, but iberiotoxin-insensitive, K+ channels are activated by stimulation with norepinephrine and electrical field stimulation to counteract the adrenergic-induced contractions of human vas deferens. Thus, inhibition of these channels increases significantly the contraction, an effect that appears to be mediated by an increase in Ca2+ entry through L-type voltage-dependent Ca2+ channels. |
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