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Molecular characterization of a chromosomal rearrangement involved in the adaptative evolution of yeast strains

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Molecular characterization of a chromosomal rearrangement involved in the adaptative evolution of yeast strains

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Pérez Ortín, José Enrique; Querol Simón, Amparo; Puig Todolí, Sergi; Barrio Esparducer, Eladio

Aquest document és un/a article, creat/da en: 2002

Este documento está disponible también en : 10.1101/gr.436602

Wine yeast strains show a high level of chromosome length polymorphism. This polymorphism is mainly generated by illegitimate recombination mediated by Ty transposons or subtelomeric repeated sequences. We have found, however, that the SSU1-R allele, which confers sulfite resistance to yeast cells, is the product of a reciprocal translocation between chromosomes VIII and XVI due to unequal crossing-over mediated by microhomology between very short sequences on the 5' upstream regions of the SSU1 and ECM34 genes. We also show that this translocation is only present in wine yeast strains, suggesting that the use for millennia of sulfite as a preservative in wine production could have favored its selection. This is the first time that a gross chromosomal rearrangement is shown to be involved in the adaptive evolution of Saccharomyces cerevisiae.

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