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SUS1, a functional component of the SAGA transcription complex and the mRNA export machinery.

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SUS1, a functional component of the SAGA transcription complex and the mRNA export machinery.

dc.contributor.author	Rodríguez Navarro, Susana
dc.contributor.author	Luo, Ming Juan
dc.contributor.author	Antúnez Temporal, Oreto
dc.contributor.author	Pérez Ortín, José Enrique
dc.contributor.author	Reed, Robin
dc.contributor.author	Hurt, Ed
dc.contributor.author	Fischer, Tomás
dc.contributor.author	Brettschneider, Susanne
dc.date.accessioned	2013-12-02T13:56:46Z
dc.date.available	2013-12-02T13:56:46Z
dc.date.issued	2004
dc.identifier.citation	Rodríguez-Navarro, Susana Luo, Ming Juan Antúnez, Oreto Pérez-Ortín, J.E. Reed, Robin Hurt, Ed Fischer, Tomás Brettschneider, Susanne 2004 SUS1, a functional component of the SAGA transcription complex and the mRNA export machinery. Cell 116 1 75 86
dc.identifier.uri	http://hdl.handle.net/10550/31688
dc.description.abstract	Gene expression is a coordinated multistep process that begins with transcription and RNA processing in the nucleus followed by mRNA export to the cytoplasm for translation. Here we report the identification of a protein, Sus1, which functions in both transcription and mRNA export. Sus1 is a nuclear protein with a concentration at the nuclear pores. Biochemical analyses show that Sus1 interacts with SAGA, a large intranuclear histone acetylase complex involved in transcription initiation, and with the Sac3-Thp1 complex, which functions in mRNA export with specific nuclear pore proteins at the nuclear basket. DNA macroarray analysis revealed that Sus1 is required for transcription regulation. Moreover, chromatin immunoprecipitation showed that Sus1 is associated with the promoter of a SAGA-dependent gene during transcription activation. Finally, mRNA export is impaired in sus1 mutants. These data provide an unexpected connection between the SAGA histone acetylase complex and the mRNA export machinery.
dc.relation.ispartof	Cell, 2004, vol. 116, num. 1, p. 75-86
dc.subject	Genètica molecular
dc.subject	Saccharomyces
dc.title	SUS1, a functional component of the SAGA transcription complex and the mRNA export machinery.
dc.type	journal article	es_ES
dc.date.updated	2013-12-02T13:56:46Z
dc.identifier.doi	10.1016/S0092-8674(03)01025-0
dc.identifier.idgrec	001839
dc.rights.accessRights	open access	es_ES
dc.identifier.url	10.1016/S0092-8674(03)01025-0