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Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis

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Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis

dc.contributor.author	Haimovich, G.
dc.contributor.author	Medina Salas, Daniel Alejandro
dc.contributor.author	Causse, S.Z.
dc.contributor.author	Garber, M.
dc.contributor.author	Millán-Zambrano, G.
dc.contributor.author	Barkai, O.
dc.contributor.author	Chávez, Sebastián
dc.contributor.author	Pérez Ortín, José Enrique
dc.contributor.author	Darzacq, X.
dc.contributor.author	Choder, M.
dc.date.accessioned	2013-12-03T08:42:52Z
dc.date.available	2013-12-03T08:42:52Z
dc.date.issued	2013
dc.identifier.citation	Haimovich, G. Medina Salas, Daniel A. Causse, S.Z. Garber, M. Millán-Zambrano, G. Barkai, O. Chávez, S, Pérez Ortín, José Enrique Darzacq, X. Choder, M. 2013 Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis Cell 153 5 1000 1011
dc.identifier.uri	http://hdl.handle.net/10550/31693
dc.description.abstract	Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The balance between mRNA synthesis and decay determines these levels. We demonstrate that most yeast mRNAs are degraded by the cytoplasmic 5′-to-3′ pathway (the"decaysome"), as proposed previously. Unexpectedly, the level of these mRNAs is highly robust to perturbations in this major pathway because defects in various decaysome components lead to transcription downregulation. Moreover, these components shuttle between the cytoplasm and the nucleus, in a manner dependent on proper mRNA degradation. In the nucleus, they associate with chromatin preferentially ∼30 bp upstream of transcription start-sites and directly stimulate transcription initiation and elongation. The nuclear role of the decaysome in transcription is linked to its cytoplasmic role in mRNA decay; linkage, in turn, seems to depend on proper shuttling of its components. The gene expression process is therefore circular, whereby the hitherto first and last stages are interconnected.
dc.relation.ispartof	Cell, 2013, vol. 153, num. 5, p. 1000-1011
dc.subject	Genètica molecular
dc.subject	RNA
dc.title	Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis
dc.type	journal article	es_ES
dc.date.updated	2013-12-03T08:42:52Z
dc.identifier.doi	10.1016/j.cell.2013.05.012
dc.identifier.idgrec	086037
dc.rights.accessRights	open access	es_ES
dc.identifier.url	10.1016/j.cell.2013.05.012