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Genome-wide studies of mRNA synthesis and degradation in eukaryotes

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Genome-wide studies of mRNA synthesis and degradation in eukaryotes

dc.contributor.author	Pérez Ortín, José Enrique
dc.contributor.author	De Miguel-Jiménez, Lola
dc.contributor.author	Chávez, Sebastián
dc.date.accessioned	2013-12-04T09:34:05Z
dc.date.available	2013-12-04T09:34:05Z
dc.date.issued	2012
dc.identifier.citation	Pérez Ortín, José Enrique De Miguel-Jiménez, Lola Chávez, Sebastián 2012 Genome-wide studies of mRNA synthesis and degradation in eukaryotes Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms 1819 6 604 615
dc.identifier.uri	http://hdl.handle.net/10550/31702
dc.description.abstract	In recent years, the use of genome-wide technologies has revolutionized the study of eukaryotic transcription producing results for thousands of genes at every step of mRNA life. The statistical analyses of the results for a single condition, different conditions, different transcription stages, or even between different techniques, is outlining a totally new landscape of the eukaryotic transcription process. Although most studies have been conducted in the yeast Saccharomyces cerevisiae as a model cell, others have also focused on higher eukaryotes, which can also be comparatively analyzed. The picture which emerges is that transcription is a more variable process than initially suspected, with large differences between genes at each stage of the process, from initiation to mRNA degradation, but with striking similarities for functionally related genes, indicating that all steps are coordinately regulated. This article is part of a Special Issue entitled: Nuclear Transport and RNA Processing.
dc.relation.ispartof	Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 2012, vol. 1819, num. 6, p. 604-615
dc.subject	Genòmica
dc.subject	Genètica molecular
dc.subject	RNA
dc.title	Genome-wide studies of mRNA synthesis and degradation in eukaryotes
dc.type	journal article	es_ES
dc.date.updated	2013-12-04T09:34:05Z
dc.identifier.doi	10.1016/j.bbagrm.2011.12.002
dc.identifier.idgrec	081460
dc.rights.accessRights	open access	es_ES
dc.identifier.url	10.1016/j.bbagrm.2011.12.002