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The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression

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The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression

dc.contributor.author	Grund, S.E.
dc.contributor.author	Fischer, Tomás
dc.contributor.author	Cabal, G.G.
dc.contributor.author	Antúnez Temporal, Oreto
dc.contributor.author	Pérez Ortín, José Enrique
dc.contributor.author	Hurt, E.
dc.date.accessioned	2013-12-09T08:09:35Z
dc.date.available	2013-12-09T08:09:35Z
dc.date.issued	2008
dc.identifier.citation	Grund, S.E. Fischer, T. Cabal, G.G. Antúnez Temporal, Oreto Pérez Ortín, José Enrique Hurt, E. 2008 The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression Journal of Cell Biology 182 5 897 910
dc.identifier.uri	http://hdl.handle.net/10550/32057
dc.description.abstract	Inner nuclear membrane proteins containing a LEM (LAP2, emerin, and MAN1) domain participate in different processes, including chromatin organization, gene expression, and nuclear envelope biogenesis. In this study, we identify a robust genetic interaction between transcription export (TREX) factors and yeast Src1, an integral inner nuclear membrane protein that is homologous to vertebrate LEM2. DNA macroarray analysis revealed that the expression of the phosphate-regulated genes PHO11 ,PHO12 , and PHO84 is up-regulated in src1 Δ cells. Notably,these PHO genes are located in subtelomeric regionsof chromatin and exhibit a perinuclear location in vivo. Src1 spans the nuclear membrane twice and exposes its N and C domains with putative DNA-binding motifs to the nucleoplasm. Genome-wide chromatin immunoprecipitation<br> on-chip analyses indicated that Src1 is highly enriched at telomeres and subtelomeric regions of the yeast chromosomes. Our data show that the inner nuclear membrane protein Src1 functions at the interface between subtelomeric gene expression and TREX-dependent messenger RNA export through the nuclear pore complexes.
dc.relation.ispartof	Journal of Cell Biology, 2008, vol. 182, num. 5, p. 897-910
dc.subject	Genètica molecular
dc.subject	Genòmica
dc.subject	Expressió genètica
dc.title	The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression
dc.type	journal article	es_ES
dc.date.updated	2013-12-09T08:09:35Z
dc.identifier.doi	10.1083/jcb.200803098
dc.identifier.idgrec	046031
dc.rights.accessRights	open access	es_ES
dc.identifier.url	10.1083/jcb.200803098