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Common gene expression strategies revealed by genome-wide analysis in yeast

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Common gene expression strategies revealed by genome-wide analysis in yeast

dc.contributor.author	García Martínez, José
dc.contributor.author	González Candelas, Fernando
dc.contributor.author	Pérez Ortín, José Enrique
dc.date.accessioned	2013-12-09T08:46:18Z
dc.date.available	2013-12-09T08:46:18Z
dc.date.issued	2007
dc.identifier.citation	García Martínez, José González Candelas, Fernando Pérez Ortín, José Enrique 2007 Common gene expression strategies revealed by genome-wide analysis in yeast Genome Biology 8 R222
dc.identifier.uri	http://hdl.handle.net/10550/32059
dc.description.abstract	Background: Gene expression is a two-step synthesis process that ends with the necessary amount of each protein required to perform its function. Since the protein is the final product, the main focus of gene regulation should be centered on it. However, because mRNA is an intermediate step and the amounts of both mRNA and protein are controlled by their synthesis and degradation rates, the desired amount of protein can be achieved following different strategies. Results: In this paper we present the first comprehensive analysis of the relationships among the six variables that characterize gene expression in a living organism: transcription and translation rates, mRNA and protein amounts, and mRNA and protein stabilities. We have used previously published data from exponentially growing Saccharomyces cerevisiae cells. We show that there is a general tendency to harmonize the levels of mRNA and protein by coordinating their synthesis rates and that functionally related genes tend to have similar values for the six variables. Conclusion: We propose that yeast cells use common expression strategies for genes acting in the same physiological pathways. This trend is more evident for genes coding for large and stable protein complexes, such as ribosomes or the proteasome. Hence, each functional group can be defined by a 'six variable profile' that illustrates the common strategy followed by the genes included in it. Genes encoding subunits of protein complexes show a tendency to have relatively unstable mRNAs and a less balanced profile for mRNA than for protein, suggesting a stronger regulation at the transcriptional level
dc.relation.ispartof	Genome Biology, 2007, vol. 8, p. R222
dc.subject	Expressió genètica
dc.subject	Saccharomyces cerevisiae
dc.subject	Saccharomyces
dc.title	Common gene expression strategies revealed by genome-wide analysis in yeast
dc.type	journal article	es_ES
dc.date.updated	2013-12-09T08:46:18Z
dc.identifier.doi	10.1186/gb-2007-8-10-r222
dc.identifier.idgrec	039044
dc.rights.accessRights	open access	es_ES
dc.identifier.url	10.1186/gb-2007-8-10-r222