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Genomics of mRNA turnover

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Genomics of mRNA turnover

dc.contributor.author	Pérez Ortín, José Enrique
dc.date.accessioned	2013-12-09T09:42:22Z
dc.date.available	2013-12-09T09:42:22Z
dc.date.issued	2007
dc.identifier.citation	Pérez Ortín, José Enrique 2007 Genomics of mRNA turnover Briefings in Functional Genomics & Proteomics 6 4 282 291
dc.identifier.uri	http://hdl.handle.net/10550/32062
dc.description.abstract	Most studies on eukaryotic gene regulation have focused on mature mRNA levels. Nevertheless, the steady-state mRNA level is the result of two opposing biological processes: transcription and degradation, both of which can be important points to regulate gene expression. It is now possible to determine the transcription and degradation rates (TR and DR), as well as the mRNA amount, for each gene using DNA chip technologies. In this way, each individual contribution to gene expression can be analysed. This review will deal with the techniques used for the genomic evaluation of TR and DR developed for the yeast Saccharomyces cerevisiae. They will be described in detail and their potential drawbacks discussed. I will also discuss the integration of the data obtained to fully analyse the expression strategies used by yeast and other eukaryotic cells.
dc.relation.ispartof	Briefings in Functional Genomics & Proteomics, 2007, vol. 6, num. 4, p. 282-291
dc.subject	Genòmica
dc.subject	Saccharomyces cerevisiae
dc.subject	RNA
dc.subject	ADN
dc.subject	Transcripció genètica
dc.title	Genomics of mRNA turnover
dc.type	journal article	es_ES
dc.date.updated	2013-12-09T09:42:22Z
dc.identifier.doi	10.1093/bfgp/elm029
dc.identifier.idgrec	041243
dc.rights.accessRights	open access	es_ES
dc.identifier.url	10.1093/bfgp/elm029