NAGIOS: RODERIC FUNCIONANDO

Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery

dc.contributor.author	Alabadí Ferrer, José Antonio
dc.contributor.author	Miranda Alonso, Francisco Javier
dc.contributor.author	Lloréns, Silvia
dc.contributor.author	Centeno Guil, José M.
dc.contributor.author	González Marrachelli, Vannina Elena
dc.contributor.author	Alborch Domínguez, Enrique
dc.date.accessioned	2013-12-09T13:51:47Z
dc.date.available	2013-12-09T13:51:47Z
dc.date.issued	2004
dc.identifier.citation	Alabadí Ferrer, José Antonio Miranda Alonso, Francisco Javier Lloréns, Silvia Centeno Guil, José M González Marrachelli, Vannina Elena Alborch Dominguez, Enrique 2004 Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery. European Journal of Pharmacology 486 289 296
dc.identifier.uri	http://hdl.handle.net/10550/32082
dc.description.abstract	The influence of alloxan-induced diabetes on the reactivity of rabbit basilar artery to endothelin-1 was examined. Endothelin-1 induced concentration-dependent contraction of basilar arteries that was higher in diabetic than in control rabbits. Endothelium removal produced a higher enhancement of the endothelin-1-induced contraction in control than in diabetic rabbits. NG-nitro-L-arginine (L-NOArg) enhanced the maximal contraction induced by endothelin-1 in control rabbits and potentiated this response in diabetic rabbits. Endothelin ETA receptor antagonist, cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123), inhibited endothelin-1-induced contraction in both rabbit groups. Endothelin ETB receptor antagonist, 2,6-Dimethylpiperidinecarbonyl-g-Methyl Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle (BQ-788), enhanced endothelin-1-induced contraction in control rabbits and decreased the potency of endothelin-1 in diabetic rabbits. Sodium nitroprusside-induced relaxation of basilar arteries was lower in diabetic than in control rabbits. These results suggest that mechanisms underlying rabbit basilar artery hyperreactivity to endothelin-1 include decreased endothelial modulation of endothelin-1-induced contraction, with impaired endothelial endothelin ETB receptor activity; decreased sensitivity to nitric oxide (NO) in vascular smooth muscle; and enhanced participation of muscular endothelin ETA and ETB receptors.
dc.relation.ispartof	European Journal of Pharmacology, 2004, vol. 486, p. 289-296
dc.subject	Endoteli vascular
dc.subject	Òxid nítric
dc.subject	Diabetis
dc.subject	Artèries
dc.title	Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery
dc.type	journal article	es_ES
dc.date.updated	2013-12-09T13:51:47Z
dc.identifier.doi	10.1016/j.ejphar.2004.01.005
dc.identifier.idgrec	014187
dc.rights.accessRights	open access	es_ES
dc.identifier.url	10.1016/j.ejphar.2004.01.005