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Experimental diabetes induces hyperreactivity of rabbit renal artery to 5-hydroxytryptamine

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Experimental diabetes induces hyperreactivity of rabbit renal artery to 5-hydroxytryptamine

dc.contributor.author	Miranda Alonso, Francisco Javier
dc.contributor.author	Alabadí Ferrer, José Antonio
dc.contributor.author	Lloréns, Silvia
dc.contributor.author	Ruiz de Apodaca, Rosa F.
dc.contributor.author	Centeno Guil, José M.
dc.contributor.author	Alborch Domínguez, Enrique
dc.date.accessioned	2013-12-09T14:00:50Z
dc.date.available	2013-12-09T14:00:50Z
dc.date.issued	2002
dc.identifier.citation	Miranda Alonso, Francisco Javier Alabadí Ferrer, José Antonio Lloréns, Silvia Ruiz de Apodaca, Rosa F Centeno Guil, José M Alborch Dominguez, Enrique 2002 Experimental diabetes induces hyperreactivity of rabbit renal artery to 5-hydroxytryptamine. European Journal of Pharmacology 439 121 127
dc.identifier.uri	http://hdl.handle.net/10550/32083
dc.description.abstract	The influence of diabetes on the response of isolated rabbit renal arteries to 5-hydroxytryptamine (5-HT) was examined. 5-HT induced a concentration-related contraction that was higher in arteries from diabetic rabbits than in arteries from control rabbits. Endothelium removal did not significantly modify 5-HT contractions in arteries from control rabbits but enhanced the response to 5-HT in arteries from diabetic rabbits. Incubation with NG-nitro-L-arginine (L-NA) enhanced contractions to 5-HT in arteries from control and diabetic rabbits. In arteries with endothelium, this L-NA enhancement was lower in diabetic rabbits than in control rabbits. In arteries without endothelium, incubation with L-NA enhanced the maximal contractions to 5-HT in control rabbits but did not in diabetic rabbits. Indomethacin inhibited 5-HT-induced contraction of arteries from control rabbits and enhanced the maximal contraction to 5-HT of arteries from diabetic rabbits. In summary, diabetes enhances contractile response of rabbit renal artery to 5-HT. In control animals, this response is regulated by both endothelial and non-endothelial (neuronal) nitric oxide (NO) and by a vasoconstrictor prostanoid. Diabetes impairs the release of non-endothelial NO and the vasoconstrictor prostanoid
dc.relation.ispartof	European Journal of Pharmacology, 2002, vol. 439, p. 121-127
dc.subject	Diabetis
dc.subject	Òxid nítric
dc.subject	Endoteli vascular
dc.subject	Artèries
dc.title	Experimental diabetes induces hyperreactivity of rabbit renal artery to 5-hydroxytryptamine
dc.type	journal article	es_ES
dc.date.updated	2013-12-09T14:00:50Z
dc.identifier.idgrec	021575
dc.rights.accessRights	open access	es_ES