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Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries

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Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries

dc.contributor.author	Alabadí Ferrer, José Antonio
dc.contributor.author	Miranda Alonso, Francisco Javier
dc.contributor.author	Lloréns, Silvia
dc.contributor.author	Ruiz de Apodaca, Rosa F.
dc.contributor.author	Centeno Guil, José M.
dc.contributor.author	Alborch Domínguez, Enrique
dc.date.accessioned	2013-12-09T14:07:15Z
dc.date.available	2013-12-09T14:07:15Z
dc.date.issued	2001
dc.identifier.citation	Alabadí Ferrer, José Antonio Miranda Alonso, Francisco Javier Lloréns, Silvia Ruiz de Apodaca, Rosa F Centeno Guil, José M Alborch Dominguez, Enrique 2001 Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries. European Journal of Pharmacology 415 225 232
dc.identifier.uri	http://hdl.handle.net/10550/32084
dc.description.abstract	The response of rabbit renal arteries to acetylcholine and its endothelial modulation in diabetes were investigated. Acetylcholine induced concentration-related endothelium-dependent relaxation of renal arteries that was significantly more potent in diabetic rabbits than in control rabbits. Pretreatment with NG-nitro-L-arginine L-NOArg., indomethacin, or L-NOArg plus indomethacin induced partial inhibition of acetylcholine-induced relaxation. Inhibition induced by L-NOArg plus indomethacin was significantly higher in arteries from diabetic rabbits than in arteries from control rabbits. In renal arteries depolarised with KCl 30 mM and incubated with L-NOArg plus indomethacin, acetylcholine-induced relaxation was almost abolished in both groups of rabbits and this response was not different from that obtained in arteries without endothelium. Sodium nitroprusside induced concentration-dependent relaxation of renal arteries from control and diabetic rabbits without significant differences between the two groups of animals. These results suggest that diabetes potentiates the acetylcholine-induced relaxation in rabbit renal arteries. Increased release of nitric oxide and prostacyclin could be responsible for the enhanced relaxant potency of acetylcholine in diabetes.
dc.relation.ispartof	European Journal of Pharmacology, 2001, vol. 415, p. 225-232
dc.subject	Òxid nítric
dc.subject	Diabetis
dc.subject	Endoteli vascular
dc.subject	Artèries
dc.title	Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries
dc.type	journal article	es_ES
dc.date.updated	2013-12-09T14:07:15Z
dc.identifier.idgrec	021576
dc.rights.accessRights	open access	es_ES