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Diabetes-induced changes in endothelial mechanisms implicated in rabbit carotid arterial response to 5-hydroxytryptamine

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Diabetes-induced changes in endothelial mechanisms implicated in rabbit carotid arterial response to 5-hydroxytryptamine

dc.contributor.author	Miranda Alonso, Francisco Javier
dc.contributor.author	Alabadí Ferrer, José Antonio
dc.contributor.author	Lloréns, Silvia
dc.contributor.author	Ruiz de Apodaca, Rosa F.
dc.contributor.author	Centeno Guil, José M.
dc.contributor.author	Alborch Domínguez, Enrique
dc.date.accessioned	2013-12-09T14:19:38Z
dc.date.available	2013-12-09T14:19:38Z
dc.date.issued	2000
dc.identifier.citation	Miranda Alonso, Francisco Javier Alabadí Ferrer, José Antonio Lloréns, Silvia Ruiz de Apodaca, Rosa F Centeno Guil, José M Alborch Dominguez, Enrique 2000 Diabetes-induced changes in endothelial mechanisms implicated in rabbit carotid arterial response to 5-hydroxytryptamine. European Journal of Pharmacology 401 397 402
dc.identifier.uri	http://hdl.handle.net/10550/32085
dc.description.abstract	The influence of diabetes on endothelial mechanisms implicated in the response of isolated rabbit carotid arteries to 5-hydroxytryptamine (5-HT)was studied. 5-HT induced a concentration<br>dependent contraction that was potentiated in arteries from diabetic rabbits with respect to that in arteries from control rabbits. Endothelium removal potentiated 5-HT contractions in arteries from both control and diabetic rabbits but increased the maximum effect only in arteries from diabetic rabbits. Incubation of arterial segments with Nº-nitro-L-arginine(L-NA)enhanced the contractile response to 5-HT. This L-NA enhancement was greater in arteries from diabetic rabbits than in arteries from control rabbits. Aminoguanidine did not modify the 5-HT contraction in arteries from control and diabetic rabbits. Indomethacin inhibited the 5-HT-induced response, and this inhibition was higher in arteries from control rabbits than in arteries from diabetic rabbits. In summary, diabetes enhances the sensitivity of the rabbit carotid artery to 5-HT. In control animals, the endothelium modulated the arterial response to 5-HT by the release of both nitric oxide (NO) and a vasoconstrictor prostanoid. Diabetes enhances endothelial constitutive NO activity and impairs the production of the endothelial vasoconstrictor
dc.relation.ispartof	European Journal of Pharmacology, 2000, vol. 401, p. 397-402
dc.subject	Diabetis
dc.subject	Òxid nítric
dc.subject	Endoteli vascular
dc.subject	Artèries
dc.title	Diabetes-induced changes in endothelial mechanisms implicated in rabbit carotid arterial response to 5-hydroxytryptamine
dc.type	journal article	es_ES
dc.date.updated	2013-12-09T14:19:38Z
dc.identifier.idgrec	021577
dc.rights.accessRights	open access	es_ES