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Contribution of endothelin receptors and cyclooxygenase-derivatives to the altered response of the rabbit renal artery to endothelin-1 in diabetes

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Contribution of endothelin receptors and cyclooxygenase-derivatives to the altered response of the rabbit renal artery to endothelin-1 in diabetes

dc.contributor.author	González Marrachelli, Vannina Elena
dc.contributor.author	Miranda Alonso, Francisco Javier
dc.contributor.author	Alabadí Ferrer, José Antonio
dc.contributor.author	Lloréns, Silvia
dc.contributor.author	Alborch Domínguez, Enrique
dc.date.accessioned	2014-02-11T10:19:01Z
dc.date.available	2014-02-11T10:19:01Z
dc.date.issued	2006
dc.identifier.citation	González Marrachelli, Vannina Elena Miranda Alonso, Francisco Javier Alabadí Ferrer, José Antonio Lloréns, Silvia Alborch Dominguez, Enrique 2006 Contribution of endothelin receptors and cyclooxygenase-derivatives to the altered response of the rabbit renal artery to endothelin-1 in diabetes European Journal of Pharmacology 534 178 186
dc.identifier.uri	http://hdl.handle.net/10550/32870
dc.description.abstract	The influence of diabetes on regulatory mechanisms and specific receptors implicated in the response of isolated rabbit renal artery to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was less potent in arteries from diabetic rabbits than in arteries from control rabbits. Endothelium removal or NG-nitro-L-arginine (L-NOARG) enhanced contractions to endothelin-1 either in control and diabetic arteries. Indomethacin inhibited endothelin-1-induced response in control arteries, but enhanced it in diabetic arteries. In contrast to that observed in rubbed and in L-NOARG treated arteries, in the presence of indomethacin the contractile action of endothelin-1 was higher in diabetic arteries than in control arteries. Nimesulide enhanced endothelin-1 contractions both in control and diabetic arteries. Cyclo-(D-Asp-Pro-DVal-Leu-D-Trp) (BQ-123, endothelin ETA receptor antagonist), attenuated endothelin-1 vasoconstriction in control rabbits, while vasoconstriction resulted increased in diabetic rabbits. 2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle (BQ-788, endothelin ETB receptor antagonist), enhanced the contractile response in control rabbit arteries without modifying this response in diabetic rabbits. In summary, diabetes decreases the sensitivity of the rabbit renal artery to endothelin-1 by decreasing the ratio between vasoconstrictor and vasodilator prostanoids released after activation of endothelin ETA receptors.
dc.relation.ispartof	European Journal of Pharmacology, 2006, vol. 534, p. 178-186
dc.subject	Diabetis
dc.subject	Endoteli vascular
dc.subject	Òxid nítric
dc.subject	Artèries
dc.title	Contribution of endothelin receptors and cyclooxygenase-derivatives to the altered response of the rabbit renal artery to endothelin-1 in diabetes
dc.type	journal article	es_ES
dc.date.updated	2014-02-11T10:19:01Z
dc.identifier.idgrec	024180
dc.rights.accessRights	open access	es_ES