NAGIOS: RODERIC FUNCIONANDO

MARTX of Vibrio vulnificus biotype 2 is a virulence and survival factor

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

MARTX of Vibrio vulnificus biotype 2 is a virulence and survival factor

dc.contributor.author	Amaro González, Carmen
dc.contributor.author	Pajuelo Gámez, David
dc.contributor.author	Llorens, Amparo
dc.contributor.author	Lee, Chung-Te
dc.contributor.author	Chen, Yi-Hsuan
dc.contributor.author	Leiro, José M.
dc.contributor.author	Padrós, Francesc
dc.contributor.author	Hor, Lien-I.
dc.date.accessioned	2014-02-26T10:15:30Z
dc.date.available	2014-02-26T10:15:30Z
dc.date.issued	2013
dc.identifier.citation	Amaro González, Carmen Pajuelo Gámez, David Llorens, Amparo Lee, Chung-Te Chen, Yi-Hsuan Leiro, José M. Padrós, Francesc Hor Lien-I 2013 MARTX of Vibrio vulnificus biotype 2 is a virulence and survival factor Environmental Microbiology 15 2 419 432
dc.identifier.uri	http://hdl.handle.net/10550/33335
dc.description.abstract	Vibrio vulnificus biotype 2 is a polyphyletic group whose virulence for fish relies on a plasmid. This plasmid contains an rtxA gene duplicated in the small chromosome that encodes a MARTX (Multifunctional, Autoprocessing Repeats-in-Toxin) unique within the species in domain structure (MARTX type III). To discover the role of this toxin in the fitness of this biotype in the fish-farming environment, single- and double-knockout mutants were isolated from a zoonotic strain and analysed in a series of in vivo and in vitro experiments with eel, fish cell lines and amoebae isolated from gills. Mice, murine and human cell lines were also assayed for comparative purposes. The results suggest that MARTX type III is involved in the lysis of a wide range of eukaryotic cells, including the amoebae, erythrocytes, epithelial cells and phagocytes after bacterium¿cell contact. In fish, MARTX type III may act as a toxin involved in the onset of septic shock, while in mice it may promote bacterial colonization by preventing phagocytosis of bacterial cells. Moreover, this toxin could protect bacteria from predation by amoebae, which would increase bacterial survival outside the host and would explain the fitness of this biotype in the fish-farming environment.
dc.relation.ispartof	Environmental Microbiology, 2013, vol. 15, num. 2, p. 419-432
dc.subject	Microbiologia
dc.title	MARTX of Vibrio vulnificus biotype 2 is a virulence and survival factor
dc.type	journal article	es_ES
dc.date.updated	2014-02-26T10:15:31Z
dc.identifier.doi	10.1111/j.1462-2920.2012.02854.x
dc.identifier.idgrec	093679
dc.rights.accessRights	open access	es_ES
dc.identifier.url	10.1111/j.1462-2920.2012.02854.x