NAGIOS: RODERIC FUNCIONANDO

Domain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus.

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Domain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus.

dc.contributor.author	Roig Molina, Francisco José
dc.contributor.author	González Candelas, Fernando
dc.contributor.author	Amaro González, Carmen
dc.date.accessioned	2014-03-03T12:07:14Z
dc.date.available	2014-03-03T12:07:14Z
dc.date.issued	2011
dc.identifier.citation	Roig Molina, Francisco José González Candelas, Fernando. Amaro González, Carmen 2011 Domain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus. Applied and Environmental Microbiology 77 2 657 668
dc.identifier.uri	http://hdl.handle.net/10550/33416
dc.description.abstract	The objective of this study was to analyze multifunctional autoprocessing repeats-in-toxin (MARTX) toxin domain organization within the aquatic species Vibrio vulnificus as well as to study the evolution of the rtxA1 gene. The species is subdivided into three biotypes that differ in host range and geographical distribution. We have found three different types (I, II, and III) of V. vulnificus MARTX (MARTXVv) toxins with common domains (an autocatalytic cysteine protease domain [CPD], an / -hydrolase domain, and a domain resembling that of the LifA protein of Escherichia coli O127:H6 E2348/69 [Efa/LifA]) and specific domains (a Rho-GTPase inactivation domain [RID], a domain of unknown function [DUF],a domain resembling that of the rtxA protein of Photorhabdus asymbiotica [rtxAPA], and an actin cross-linking domain [ACD]). Biotype 1 isolates harbor MARTXVv toxin types I and II, biotype 2 isolates carry MARTXVv toxin type III, and biotype 3 isolates have MARTXVv toxin type II. The analyzed biotype 2 isolates harbor two identical copies of rtxA1, one chromosomal and the other plasmidic. The evolutionary history of the gene demonstrates that MARTXVv toxins are mosaics, comprising pieces with different evolutionary histories, some of which have been acquired by intra- or interspecific horizontal gene transfer. Finally, we have found evidence that the evolutionary history of the rtxA1 gene for biotype 2 differs totally from the gene history of biotypes 1 and 3.
dc.relation.ispartof	Applied and Environmental Microbiology, 2011, vol. 77, num. 2, p. 657-668
dc.subject	Bacteris patògens
dc.subject	Bacteris
dc.subject	Genètica bacteriana
dc.title	Domain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus.
dc.type	journal article	es_ES
dc.date.updated	2014-03-03T12:07:14Z
dc.identifier.doi	10.1128/AEM.01806-10
dc.identifier.idgrec	075975
dc.rights.accessRights	open access	es_ES
dc.identifier.url	10.1128/AEM.01806-10