Application of mesenchymal stem cells in bone regenerative procedures in oral implantology. A literature review
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Viña Almunia, José; El Alami, Marya; Gambini Ricapa, Juan; Borrás Blasco, Consuelo; Viña Ribes, José; Peñarrocha, María A.
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Aquest document és un/a article, creat/da en: 2014
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Objective: The aim of this work was to review de literature about the role of mesenchymal stem cells in bone regenerative
procedures in oral implantology, specifically, in the time require to promote bone regeneration.
Study Desing: A bibliographic search was carried out in PUBMED with a combination of different key words.
Animal and human studies that assessed histomorphometrically the influence of mesenchymal stem cells on bone
regeneration procedures in oral implantology surgeries were examined.
Reults:
- Alveolar regeneration: Different controlled histomorphometric animal studies showed that bone regeneration is
faster using stem cells seeded in scaffolds than using scaffolds or platelet rich plasma alone. Human studies revealed
that stem cells increase bone regeneration.
- Maxillary sinus lift: Controlled studies in animals and in humans showed higher bone regeneration applying stem
cells compared with controls.
- Periimplantary bone regeneration and alveolar distraction: Studies in animals showed higher regeneration when
stem cells are used. In humans, no evidence of applying mesenchymal stem cells in these regeneration procedures
was found.
Conclusion: Stem cells may promote bone regeneration and be useful in bone regenerative procedures in oral implantology,
but no firm conclusions can be drawn from the rather limited clinical studies so far performed.
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