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Bone metabolism and clinical study of 44 patients with bisphosphonate-related osteonecrosis of the jaws

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Bone metabolism and clinical study of 44 patients with bisphosphonate-related osteonecrosis of the jaws

dc.contributor.author	Bocanegra Pérez, Sacramento	es
dc.contributor.author	Vicente Barrero, Mario	es
dc.contributor.author	Sosa Henríquez, Manuel	es
dc.contributor.author	Rodríguez Bocanegra, Eduardo	es
dc.contributor.author	Limiñana Cañal, José María	es
dc.contributor.author	López Márquez, Ariadna	es
dc.contributor.author	Pérez Plasencia, D.	es
dc.contributor.author	Ramos Macías, Ángel	es
dc.date.accessioned	2014-05-28T12:42:51Z
dc.date.available	2014-05-28T12:42:51Z
dc.date.issued	2012	es
dc.identifier.citation	Bocanegra Pérez, Sacramento ; Vicente Barrero, Mario ; Sosa Henríquez, Manuel ; Rodríguez Bocanegra, Eduardo ; Limiñana Cañal, José María ; López Márquez, Ariadna ; Pérez Plasencia, D. ; Ramos Macías, Ángel. Bone metabolism and clinical study of 44 patients with bisphosphonate-related osteonecrosis of the jaws. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2012, Vol. 17, No. 6: 948-955	es
dc.identifier.uri	http://hdl.handle.net/10550/35526
dc.description.abstract	Osteonecrosis of the jaws is a clinical entity described and linked to treatment with bisphosphonates in 2003. Its real incidence is unknown and it could increase due to the large number of patients treated with these drugs, and its cumulative effect on the bone. State of the art knowledge regarding its etiopathogeny, clinical course and suitable treatments is limited. Objectives: To study the clinical characteristics of 44 patients with bisphosphonate-related osteonecrosis of the jaws and the state of their bone mineral metabolism: bone remodeling state, prevalence of fractures, bone mineral density study, and assessment of the different treatment strategies. Design of the Study: Observational. Information was gathered prospectively through interviews, clinical examinations, additional tests and review of medical records. Results: We studied 16 men and 28 women with a mean age of 64.7 years. Breast cancer was the most frequent underlying disease. Zoledronate was used in 82% of the cases and in the non-oncology group of patients; alendronate was the most frequently used bisphosphonate. The mean duration of the zoledronate and alendronate treatments was 25 months and 88 months respectively. The lower jaw was the most frequent location, and previous exodontias- among the triggering factors known-were the most closely linked to its onset. We found considerable osteoblastic activity in patients suffering from neoplasia, with artifacts present in their bone densitometry and a high percentage of vertebral fractures. Conclusions: According to our results, osteonecrosis of the jaws affects elderly patients. We found a direct relationship between the duration of exposure and the accumulated dose. Other relevant factors are: Poor oral and dental health, corticoids, diabetes and teeth extractions. In essence, it is a clinical diagnosis. Prevention is the best strategy to handle this clinical entity.	en_US
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Bone metabolism and clinical study of 44 patients with bisphosphonate-related osteonecrosis of the jaws	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES